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Journal Articles AJP - Regulatory, Integrative and Comparative Physiology Year : 2022

Circulating microRNA levels after exercise-induced muscle damage and the repeated bout effect

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Abstract

Introduction:The neuromuscular system is able to quickly adapt to exercise-induced muscle damage (EIMD), such that it is less affected by subsequent damaging exercise, a phenomenon known as the repeated bout effect (RBE). Circulating muscle-specific microRNAs (myomiRs) may be able to potentially predict the long-lasting maximal voluntary contraction (MVC) torque deficit (>24h), an indicator of EIMD.We aimed to investigate:(1) how plasma myomiR levels are modified by the RBE and (2) whether plasma myomiRs can predict the long-lasting MVC torque deficit.Methods:Nineteen participants performed two identical bouts of loaded downhill walking separated by two weeks.MVC torque, creatine kinase (CK) activity, myoglobin (Mb) concentration, and myomiR levels were measured before and up to 48h after exercise.Correlation and multiple regression analyses were performed to assess the ability of these markers to predict the largest MVC torque loss beyond 24h post-exercise.Results:Similar to MVC torque, CK activity, and the Mb concentration, the relative abundance of certain myomiRs (hsa-miR-1-3p, hsa-miR-133a-3p) were less affected after the second bout of exercise relative to the first bout.The CK activity, Mb concentration and level of several myomiRs (hsa-miR-1-3p, hsa-miR-133a-3p, hsa-miR-206) correlated with long-lasting MVC torque loss.Multiple regression showed that the best combination of markers to predict the long-lasting deficit of MVC torque included several myomiRs, Mb, and CK.Conclusion:Certain myomiR levels increased less after exercise bout 2 than after exercise bout 1, indicating the presence of the RBE.The measurement of myomiR levels in combination with Mb concentrations and CK activity could improve the prediction of the long-lasting MVC torque deficit.
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Dates and versions

hal-03888370 , version 1 (07-12-2022)

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Emeric Chalchat, Martin Vincent, Keyne Charlot, Cyprien Bourrilhon, Stéphane Baugé, et al.. Circulating microRNA levels after exercise-induced muscle damage and the repeated bout effect. AJP - Regulatory, Integrative and Comparative Physiology, 2022, ⟨10.1152/ajpregu.00096.2022⟩. ⟨hal-03888370v1⟩
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