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Article Dans Une Revue Communications Biology Année : 2022

Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia

Jérôme Salles
Christophe Rocher
Olivier Le Bacquer
Yves Boirie
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Stéphane Walrand

Résumé

Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is impaired in vitamin D-deficient subjects. In cultured myotubes, loss of vitamin D receptor (VDR) function decreases mitochondrial respiration rate and ATP production from oxidative phosphorylation. We aimed to examine the effects of vitamin D deficiency and supplementation on whole-body energy expenditure and muscle mitochondrial function in old rats, old mice, and human subjects. To gain further insight into the mechanisms involved, we used C2C12 and human muscle cells and transgenic mice with muscle-specific VDR tamoxifen-inducible deficiency. We observed that in vivo and in vitro vitamin D fluctuations changed mitochondrial biogenesis and oxidative activity in skeletal muscle. Vitamin D supplementation initiated in older people improved muscle mass and strength. We hypothesize that vitamin D supplementation is likely to help prevent not only sarcopenia but also sarcopenic obesity in vitamin D-deficient subjects.
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Dates et versions

hal-03879054 , version 1 (30-11-2022)

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Jérôme Salles, Audrey Chanet, Christelle Guillet, Anouk Mm. Vaes, Elske Brouwer-Brolsma, et al.. Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia. Communications Biology, 2022, 5 (1), pp.1288. ⟨10.1038/s42003-022-04246-3⟩. ⟨hal-03879054⟩
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