The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study
Laura Ferraro
(1)
,
Caterina La Cascia
(1)
,
Daniele La Barbera
(1)
,
Teresa Sanchez-Gutierrez
(2)
,
Giada Tripoli
(1)
,
Fabio Seminerio
(1)
,
Crocettarachele Sartorio
(1)
,
Giovanna Marrazzo
(1)
,
Lucia Sideli
(1)
,
Celso Arango
(3)
,
Manuel Arrojo
(4)
,
Miguel Bernardo
(5)
,
Julio Bobes
(6)
,
Cristina Marta Del-Ben
(7)
,
Charlotte Gayer-Anderson
(8)
,
Hannah E. Jongsma
(9)
,
James B. Kirkbride
(9)
,
Antonio Lasalvia
(10)
,
Sarah Tosato
(11)
,
Pierre Michel Llorca
(12)
,
Paulo Rossi Menezes
(13)
,
Bart P. Rutten
(14)
,
José Luis Santos
(15)
,
Julio Sanjuan
(16)
,
Jean-Paul Selten
(14, 17)
,
Andreï Szoke
(18)
,
Ilaria Tarricone
(19)
,
Roberto Muratori
(20)
,
Andrea Tortelli
(21)
,
Eva Velthorst
(22, 23)
,
Victoria Rodriguez
(8)
,
Andrea Quattrone
(24)
,
Peter B. Jones
(25)
,
Jim van Os
(8, 26)
,
Evangelos Vassos
(27)
,
Craig Morgan
(8)
,
Lieuwe de Haan
(28)
,
Ulrich Reininghaus
(8, 14, 29)
,
Alastair G. Cardno
(30)
,
Marta Di Forti
(27, 31)
,
Robin M. Murray
(31, 8)
,
D Quattrone
(31, 27, 29)
1
Università degli studi di Palermo - University of Palermo
2 Faculty of Health Science, Universidad Internacional de la Rioja (UNIR)
3 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
4 Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela
5 Barcelona Clinic Schizophrenia Unit, Department of Medicine, Neuroscience Institute, Hospital clinic, University of Barcelona, IDIBAPS, CIBERSAM
6 Universidad de Oviedo [Oviedo]
7 FMUSP - Universidade de São Paulo Medical School
8 King‘s College London
9 UCL - University College of London [London]
10 Section of Psychiatry, Azienda Ospedaliera Universitaria Integrata di Verona
11 UNIVR - Università degli studi di Verona = University of Verona
12 IP - Institut Pascal
13 Department of Preventive Medicine, Faculdade de Medicina, Universidade of São Paulo
14 Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre
15 Department of Psychiatry, Servicio de Psiquiatría Hospital "Virgen de la Luz"
16 UV - Universitat de València
17 Rivierduinen Institute for Mental Health Care
18 INSERM - Institut National de la Santé et de la Recherche Médicale
19 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
20 Dapertment of Mental Health and pathological addictions, Bologna Local Health Authority
21 Etablissement Public de Santé Maison Blanche
22 Department of Psychiatry, Early Psychosis Section, Amsterdam UMC, University of Amsterdam
23 MSSM - Icahn School of Medicine at Mount Sinai [New York]
24 National Health Service, Villa Betania Institute
25 CAM - University of Cambridge [UK]
26 Department Psychiatry, Brain Centre Rudolf Magnus, Utrecht University Medical Centre
27 Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London
28 Department of Psychiatry, Early Psychosis Section, Academic Medical Centre, University of Amsterdam
29 Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
30 University of Leeds
31 SLAM - South London and Maudsley NHS Mental Health Foundation Trust
2 Faculty of Health Science, Universidad Internacional de la Rioja (UNIR)
3 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
4 Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela
5 Barcelona Clinic Schizophrenia Unit, Department of Medicine, Neuroscience Institute, Hospital clinic, University of Barcelona, IDIBAPS, CIBERSAM
6 Universidad de Oviedo [Oviedo]
7 FMUSP - Universidade de São Paulo Medical School
8 King‘s College London
9 UCL - University College of London [London]
10 Section of Psychiatry, Azienda Ospedaliera Universitaria Integrata di Verona
11 UNIVR - Università degli studi di Verona = University of Verona
12 IP - Institut Pascal
13 Department of Preventive Medicine, Faculdade de Medicina, Universidade of São Paulo
14 Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre
15 Department of Psychiatry, Servicio de Psiquiatría Hospital "Virgen de la Luz"
16 UV - Universitat de València
17 Rivierduinen Institute for Mental Health Care
18 INSERM - Institut National de la Santé et de la Recherche Médicale
19 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
20 Dapertment of Mental Health and pathological addictions, Bologna Local Health Authority
21 Etablissement Public de Santé Maison Blanche
22 Department of Psychiatry, Early Psychosis Section, Amsterdam UMC, University of Amsterdam
23 MSSM - Icahn School of Medicine at Mount Sinai [New York]
24 National Health Service, Villa Betania Institute
25 CAM - University of Cambridge [UK]
26 Department Psychiatry, Brain Centre Rudolf Magnus, Utrecht University Medical Centre
27 Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London
28 Department of Psychiatry, Early Psychosis Section, Academic Medical Centre, University of Amsterdam
29 Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
30 University of Leeds
31 SLAM - South London and Maudsley NHS Mental Health Foundation Trust
Giada Tripoli
- Fonction : Auteur
- PersonId : 793104
- ORCID : 0000-0002-9257-6677
Ulrich Reininghaus
- Fonction : Auteur
D Quattrone
- Fonction : Auteur
Résumé
Premorbid functioning and cognitive measures may reflect gradients of developmental impairment across diagnostic categories in psychosis. In this study, we sought to examine the associations of current cognition and premorbid adjustment with symptom dimensions in a large first episode psychosis (FEP) sample.
We used data from the international EU-GEI study. Bifactor modelling of the Operational Criteria in Studies of Psychotic Illness (OPCRIT) ratings provided general and specific symptom dimension scores. Premorbid Adjustment Scale estimated premorbid social (PSF) and academic adjustment (PAF), and WAIS-brief version measured IQ. A MANCOVA model examined the relationship between symptom dimensions and PSF, PAF, and IQ, having age, sex, country, self-ascribed ethnicity and frequency of cannabis use as confounders.
In 785 patients, better PSF was associated with fewer negative (B = −0.12, 95% C.I. −0.18, −0.06, p < 0.001) and depressive (B = −0.09, 95% C.I. −0.15, −0.03, p = 0.032), and more manic (B = 0.07, 95% C.I. 0.01, 0.14, p = 0.023) symptoms. Patients with a lower IQ presented with slightly more negative and positive, and fewer manic, symptoms. Secondary analysis on IQ subdomains revealed associations between better perceptual reasoning and fewer negative (B = −0.09, 95% C.I. −0.17, −0.01, p = 0.023) and more manic (B = 0.10, 95% C.I. 0.02, 0.18, p = 0.014) symptoms. Fewer positive symptoms were associated with better processing speed (B = −0.12, 95% C.I. −0.02, −0.004, p = 0.003) and working memory (B = −0.10, 95% C.I. −0.18, −0.01, p = 0.024).
These findings suggest that the negative and manic symptom dimensions may serve as clinical proxies of different neurodevelopmental predisposition in psychosis.
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