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The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study

Laura Ferraro 1 Caterina La Cascia 1 Daniele La Barbera 1 Teresa Sanchez-Gutierrez 2 Giada Tripoli 1 Fabio Seminerio 1 Crocettarachele Sartorio 1 Giovanna Marrazzo 1 Lucia Sideli 1 Celso Arango 3 Manuel Arrojo 4 Miguel Bernardo 5 Julio Bobes 6 Cristina Marta Del-Ben 7 Charlotte Gayer-Anderson 8 Hannah E. Jongsma 9 James B. Kirkbride 9 Antonio Lasalvia 10 Sarah Tosato 11 Pierre Michel Llorca 12 Paulo Rossi Menezes 13 Bart P. Rutten 14 José Luis Santos 15 Julio Sanjuan 16 Jean-Paul Selten 14, 17 Andreï Szoke 18 Ilaria Tarricone 19 Roberto Muratori 20 Andrea Tortelli 21 Eva Velthorst 22, 23 Victoria Rodriguez 24 Andrea Quattrone 25 Peter B. Jones 26 Jim van Os 24, 27 Evangelos Vassos 28 Craig Morgan 8 Lieuwe de Haan 29 Ulrich Reininghaus 8, 14, 30 Alastair G. Cardno 31 Marta Di Forti 28, 32 Robin M. Murray 32, 24 D Quattrone 32, 28, 30 
Abstract : Premorbid functioning and cognitive measures may reflect gradients of developmental impairment across diagnostic categories in psychosis. In this study, we sought to examine the associations of current cognition and premorbid adjustment with symptom dimensions in a large first episode psychosis (FEP) sample. We used data from the international EU-GEI study. Bifactor modelling of the Operational Criteria in Studies of Psychotic Illness (OPCRIT) ratings provided general and specific symptom dimension scores. Premorbid Adjustment Scale estimated premorbid social (PSF) and academic adjustment (PAF), and WAIS-brief version measured IQ. A MANCOVA model examined the relationship between symptom dimensions and PSF, PAF, and IQ, having age, sex, country, self-ascribed ethnicity and frequency of cannabis use as confounders. In 785 patients, better PSF was associated with fewer negative (B = −0.12, 95% C.I. −0.18, −0.06, p < 0.001) and depressive (B = −0.09, 95% C.I. −0.15, −0.03, p = 0.032), and more manic (B = 0.07, 95% C.I. 0.01, 0.14, p = 0.023) symptoms. Patients with a lower IQ presented with slightly more negative and positive, and fewer manic, symptoms. Secondary analysis on IQ subdomains revealed associations between better perceptual reasoning and fewer negative (B = −0.09, 95% C.I. −0.17, −0.01, p = 0.023) and more manic (B = 0.10, 95% C.I. 0.02, 0.18, p = 0.014) symptoms. Fewer positive symptoms were associated with better processing speed (B = −0.12, 95% C.I. −0.02, −0.004, p = 0.003) and working memory (B = −0.10, 95% C.I. −0.18, −0.01, p = 0.024). These findings suggest that the negative and manic symptom dimensions may serve as clinical proxies of different neurodevelopmental predisposition in psychosis.
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https://hal.uca.fr/hal-03583977
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Laura Ferraro, Caterina La Cascia, Daniele La Barbera, Teresa Sanchez-Gutierrez, Giada Tripoli, et al.. The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study. Schizophrenia Research, Elsevier, 2021, 236, pp.69-79. ⟨10.1016/j.schres.2021.08.008⟩. ⟨hal-03583977⟩

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