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One Step Forward in Exploration of Class II Pyruvate Aldolases Nucleophile and Electrophile Substrate Specificity

Abstract : Originally named according to their strict nucleophile specificity towards pyruvate, some pyruvate aldolases were demonstrated to be able to convert other nucleophiles. This study illustrates that the nucleophile 2-oxopentanoate successfully reacted with various aldehydes and even ketones. Unknown aldols with a 3S configuration were then isolated, characterized, and their stereochemistries could be set as either 4R or 4S by choosing the appropriate aldolase.
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https://hal.uca.fr/hal-03434880
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Submitted on : Thursday, November 18, 2021 - 2:47:51 PM
Last modification on : Sunday, June 26, 2022 - 3:19:58 AM

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Cédric Gastaldi, Rolande Ngahan Tagne, Victor Laurent, Virgil Hélaine, Jean-Louis Petit, et al.. One Step Forward in Exploration of Class II Pyruvate Aldolases Nucleophile and Electrophile Substrate Specificity. ChemCatChem, Wiley, 2021, 13 (18), pp.3920-3924. ⟨10.1002/cctc.202100932⟩. ⟨hal-03434880⟩

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