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From K. pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models

Abstract : Klebsiella pneumoniae is a Gram-negative pathogen responsible for community-acquired and nosocomial infections. The strains of this species belong to the opportunistic group, which is comprised of the multidrug-resistant strains, or the hypervirulent group, depending on their accessory genome, which determines bacterial pathogenicity and the host immune response. The aim of this survey is to present an overview of the murine models mimicking K. pneumoniae infectious processes (i.e., gastrointestinal colonization, urinary, pulmonary, and systemic infections), and the bacterial functions deployed to colonize and disseminate into the host. These in vivo approaches are pivotal to develop new therapeutics to limit K. pneumoniae infections via a modulation of the immune responses and/or microbiota.
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https://hal.uca.fr/hal-03263532
Contributor : Sylvie Miquel <>
Submitted on : Thursday, June 17, 2021 - 1:35:23 PM
Last modification on : Friday, June 18, 2021 - 3:45:21 AM

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Laura Joseph, Thomas Merciecca, Christiane Forestier, Damien Balestrino, Sylvie Miquel. From K. pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models. Microorganisms, MDPI, 2021, 9 (6), pp.1282. ⟨10.3390/microorganisms9061282⟩. ⟨hal-03263532⟩

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