Given the high eruption recurrence in the Michoacán-Guanajuato volcanic field (MGVF) in central Mexico, the birth of a new monogenetic volcano can be expected in the future. It is important, therefore, to reconstruct the past eruptions of its many different volcanoes, including estimates of lava flow emplacement times and their rheological properties. These studies define the range of possible future eruptive scenarios and are necessary to evaluate potential risk. The Rancho Seco monogenetic volcano, located in the central part of the MGVF (19°37′03”N, 101°28′21”W), was radiocarbon-dated at ~27,845 years BP. Its eruption initiated with a violent-Strombolian phase that produced a scoria cone and was followed by the effusion of at least seven associated andesitic lava flows, reflecting drastic changes in the eruptive dynamics. Effusive activity probably involved decreases in the magma ascent and discharge rates linked to efficient degassing in an open system. Lava chemical composition suggest an origin of partial melting of a subduction-modified hydrated heterogenous mantle wedge and textural and mineralogical analysis indicates significant crystal fractionation and minor assimilation of granodioritic basement rocks. High-resolution LiDAR imagery was used to estimate lava flow viscosities and emplacement times by following a morphology-based methodology. Results indicate that lava flow viscosities ranged from 105 to 109 Pa·s and emplacement durations between 32 and 465 days for the flow units considered (F5 and F6). The entire eruption may have lasted from 2 to 6 years with a mean effusion rate of 4 to 15 m3/s. Our results are also pertinent to archaeologists studying the architectural remains of Angamuco, a large urban pre-Hispanic site built on Rancho Seco's lava flows.