Skip to Main content Skip to Navigation
Journal articles

Antihypertensive Drug Regimen for High Blood Pressure Associated with Modifiable Cardiovascular Risk Factors Among Hypertensive Patients Attending Campus Teaching Hospital of Lomé, Togo, West Africa

Abstract : Objective: The present prospective study was aimed to target the antihypertensive drug regimen for HBP associated with modifiable cardiovascular risk factors such as stressful and sedentary lifestyle, obesity, diabetes and chronic ethylism among hypertensive patients. Material and Method: This study was conducted among outpatients and inpatients attending the department of cardiology of Campus Teaching Hospital for hypertension conditions associated with comorbidities (stressful, sedentary lifestyle, obesity, diabetes and ethylism) and placed on antihypertensive drug therapy. Results: Of the 112 patients treated for HBP, 43 (38.39%) received an ambulatory treatment and 69 (61.61%) were hospitalized. Of 43 outpatients, 37.21% and 18.60% vs 24.64%, 34.78% and 23.19% of 69 inpatients presented respectively 2, 3 and ≥ 4 concomitant modifiable risk factors. Regarding the antihypertensive drug regimens received and concomitant risk factor profile of patients, significant reduction of Systolic Blood Pressure (SBP) among patients with 3 risk factors and Diastolic Blood Pressure (DBP) among patients with at least, together with chronic ethylism, another risk factor among stressful, sedentary lifestyle, obesity and diabetes, was observed. In cases of complicated HBP, outpatients with 3 concomitant risk factors against inpatients with high stress, sedentary lifestyle and obesity were placed on diuretic (D), Calcium Channel Antagonist (CCA) and Angiotensin Converting Enzyme Inhibitor (ACEI) as first choice in monotherapy or in addition to Centrally Acting Antihypertensive Drug (CAAD) in suitable combinations in 2/3 of total combinations prescribed. Conclusion: antihypertensive drug regimens from mono to quadruple therapy allowed to control significantly SBP in patients with 3 concomitant modifiable risk factors and DBP among patients with at least, together with chronic ethylism, another risk factor among stress, sedentarity, obesity and diabetes. In complicated HBP with concomitant modifiable risk factors, D or CCA or ACEI or in suitable combinations in addition to CAAD were the favorite pharmacological groups prescribed.
Complete list of metadata

https://hal.uca.fr/hal-03111109
Contributor : Stéphane Lolignier Connect in order to contact the contributor
Submitted on : Friday, January 15, 2021 - 9:57:47 AM
Last modification on : Wednesday, September 1, 2021 - 11:26:02 AM
Long-term archiving on: : Friday, April 16, 2021 - 6:18:05 PM

File

a13566b472cb096ad2632f0c2dda1d...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Yao Potchoo, Edem Goeh-Akue, Findibe Damorou, Stéphane Lolignier, Barima Massoka, et al.. Antihypertensive Drug Regimen for High Blood Pressure Associated with Modifiable Cardiovascular Risk Factors Among Hypertensive Patients Attending Campus Teaching Hospital of Lomé, Togo, West Africa. Journal of Pharmaceutical and Pharmacological Sciences, Gavin Publishers, 2018, 3 (1), pp.1-9. ⟨10.29011/2574-7711⟩. ⟨hal-03111109⟩

Share

Metrics

Record views

131

Files downloads

160