T. De-lange, How Telomeres Solve the End-Protection Problem, Science, vol.326, issue.5955, pp.948-952, 2009.

J. Maciejowski and T. De-lange, Telomeres in cancer: tumour suppression and genome instability, Nature Reviews Molecular Cell Biology, vol.18, issue.3, pp.175-186, 2017.

J. W. Shay and W. E. Wright, Telomeres and telomerase: three decades of progress, Nature Reviews Genetics, vol.20, issue.5, pp.299-309, 2019.

M. Armanios and E. H. Blackburn, The telomere syndromes, Nature Reviews Genetics, vol.13, issue.10, pp.693-704, 2012.

E. H. Blackburn, E. S. Epel, and J. Lin, Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection, Science, vol.350, issue.6265, pp.1193-1198, 2015.

G. Sarek, P. Marzec, P. Margalef, and S. J. Boulton, Molecular basis of telomere dysfunction in human genetic diseases, Nature Structural & Molecular Biology, vol.22, issue.11, pp.867-874, 2015.

J. D. Watson, Origin of Concatemeric T7DNA, Nature New Biology, vol.239, issue.94, pp.197-201, 1972.

J. Soudet, P. Jolivet, and M. T. Teixeira, Elucidation of the DNA End-Replication Problem in Saccharomyces cerevisiae, Molecular Cell, vol.53, issue.6, pp.954-964, 2014.

C. B. Harley, A. B. Futcher, and C. W. Greider, Telomeres shorten during ageing of human fibroblasts, Nature, vol.345, issue.6274, pp.458-460, 1990.

T. H. Nguyen, K. Collins, and E. Nogales, Telomerase structures and regulation: shedding light on the chromosome end, Current Opinion in Structural Biology, vol.55, pp.185-193, 2019.

Y. Vasianovich and R. J. Wellinger, Life and Death of Yeast Telomerase RNA, Journal of Molecular Biology, vol.429, issue.21, pp.3242-3254, 2017.

M. S. Apte and J. P. Cooper, Life and cancer without telomerase: ALT and other strategies for making sure ends (don?t) meet, Critical Reviews in Biochemistry and Molecular Biology, vol.52, issue.1, pp.57-73, 2016.

A. P. Sobinoff and H. A. Pickett, Alternative Lengthening of Telomeres: DNA Repair Pathways Converge, Trends in Genetics, vol.33, issue.12, pp.921-932, 2017.

R. L. Dilley and R. A. Greenberg, ALTernative Telomere Maintenance and Cancer, Trends in Cancer, vol.1, issue.2, pp.145-156, 2015.

S. Mocellin, K. A. Pooley, and D. Nitti, Telomerase and the search for the end of cancer, Trends in Molecular Medicine, vol.19, issue.2, pp.125-133, 2013.

M. A. Jafri, S. A. Ansari, M. H. Alqahtani, and J. W. Shay, Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies, Genome Medicine, vol.8, issue.1, p.69, 2016.

I. Draskovic and A. Londono-vallejo, Telomere Recombination and the ALT Pathway: A Therapeutic Perspective for Cancer, Current Pharmaceutical Design, vol.20, issue.41, pp.6466-6471, 2014.

J. Hu, S. S. Hwang, M. Liesa, B. Gan, E. Sahin et al., Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer, Cell, vol.148, issue.4, pp.651-663, 2012.

A. Queisser, S. Heeg, M. Thaler, A. Von-werder, and O. G. Opitz, Inhibition of telomerase induces alternative lengthening of telomeres during human esophageal carcinogenesis, Cancer Genetics, vol.206, issue.11, pp.374-386, 2013.

M. T. Teixeira, Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening, Frontiers in Oncology, vol.3, p.101, 2013.

V. Lundblad and E. H. Blackburn, An alternative pathway for yeast telomere maintenance rescues est1? senescence, Cell, vol.73, issue.2, pp.347-360, 1993.

T. M. Bryan, A. Englezou, J. Gupta, S. Bacchetti, and R. R. Reddel, Telomere elongation in immortal human cells without detectable telomerase activity., The EMBO Journal, vol.14, issue.17, pp.4240-4248, 1995.

S. Le, J. K. Moore, J. E. Haber, and C. W. Greider, Decision letter: Identification of human TERT elements necessary for telomerase recruitment to telomeres, Genetics, vol.152, pp.143-152, 2014.

V. Lundblad and J. W. Szostak, A mutant with a defect in telomere elongation leads to senescence in yeast, Cell, vol.57, issue.4, pp.633-643, 1989.

S. C. Teng and V. A. Zakian, Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in Saccharomyces cerevisiae, Molecular and Cellular Biology, vol.19, issue.12, pp.8083-8093, 1999.

H. A. Pickett and R. R. Reddel, Molecular mechanisms of activity and derepression of alternative lengthening of telomeres, Nature Structural & Molecular Biology, vol.22, issue.11, pp.875-880, 2015.

R. L. Dilley, P. Verma, N. W. Cho, H. D. Winters, A. R. Wondisford et al., Break-induced telomere synthesis underlies alternative telomere maintenance, Nature, vol.539, issue.7627, pp.54-58, 2016.

A. Malkova and G. Ira, Break-induced replication: functions and molecular mechanism, Current Opinion in Genetics & Development, vol.23, issue.3, pp.271-279, 2013.

F. M. Roumelioti, S. K. Sotiriou, V. Katsini, M. Chiourea, T. D. Halazonetis et al., Alternative lengthening of human telomeres is a conservative DNA replication process with features of break?induced replication, EMBO reports, vol.17, issue.12, pp.1731-1737, 2016.

J. R. Lydeard, S. Jain, M. Yamaguchi, and J. E. Haber, Break-induced replication and telomerase-independent telomere maintenance require Pol32, Nature, vol.448, issue.7155, pp.820-823, 2007.

J. R. Lydeard, Z. Lipkin-moore, Y. J. Sheu, B. Stillman, P. M. Burgers et al., Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly, Genes & Development, vol.24, issue.11, pp.1133-1144, 2010.

E. V. Linardopoulou, E. M. Williams, Y. Fan, C. Friedman, J. M. Young et al., Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication, Nature, vol.437, issue.7055, pp.94-100, 2005.

B. B. De-vries, R. Winter, A. Schinzel, and C. Van-ravenswaaij-arts, Telomeres: a diagnosis at the end of the chromosomes, Journal of Medical Genetics, vol.40, issue.6, pp.385-398, 2003.

S. Tashiro, Y. Nishihara, K. Kugou, K. Ohta, and J. Kanoh, Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis, Nucleic Acids Research, vol.45, issue.18, pp.10333-10349, 2017.

E. J. Louis and J. E. Haber, Seven-base-pair inverted repeats in DNA form stable hairpins in vivo in Saccharomyces cerevisiae, Trends in Genetics, vol.8, issue.2, p.50, 1992.

M. Yamada, N. Hayatsu, A. Matsuura, and F. Ishikawa, Y?-Help1, a DNA Helicase Encoded by the Yeast Subtelomeric Y? Element, Is Induced in Survivors Defective for Telomerase, Journal of Biological Chemistry, vol.273, issue.50, pp.33360-33366, 1998.

N. Grandin, S. I. Reed, and M. Charbonneau, Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13., Genes & Development, vol.11, issue.4, pp.512-527, 1997.
URL : https://hal.archives-ouvertes.fr/hal-01919624

N. Grandin and M. Charbonneau, Telomerase- and Rad52-Independent Immortalization of Budding Yeast by an Inherited-Long-Telomere Pathway of Telomeric Repeat Amplification, Molecular and Cellular Biology, vol.29, issue.4, pp.965-985, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01919492

E. J. Louis and R. H. Borts, A complete set of marked telomeres in Saccharomyces cerevisiae for physical mapping and cloning, Genetics, vol.139, pp.125-136, 1995.

H. Horowitz, P. Thorburn, and J. E. Haber, Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae., Molecular and Cellular Biology, vol.4, issue.11, pp.2509-2517, 1984.

R. J. Wellinger and V. A. Zakian, Everything You Ever Wanted to Know AboutSaccharomyces cerevisiaeTelomeres: Beginning to End, Genetics, vol.191, issue.4, pp.1073-1105, 2012.

S. Makovets, T. L. Williams, and E. H. Blackburn, The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase, Genetics, vol.178, issue.1, pp.245-257, 2008.

E. P. Mimitou and L. S. Symington, DNA end resection: Many nucleases make light work, DNA Repair, vol.8, issue.9, pp.983-995, 2009.

L. S. Symington, Mechanism and regulation of DNA end resection in eukaryotes, Critical Reviews in Biochemistry and Molecular Biology, vol.51, issue.3, pp.195-212, 2016.

Z. Yan, C. Xue, S. Kumar, J. B. Crickard, Y. Yu et al., Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast, Molecular Cell, vol.76, issue.5, pp.699-711.e6, 2019.

G. Greene and . Ira, Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast, Mol Cell, vol.76, pp.699-711, 2019.

C. Claussin and M. Chang, The many facets of homologous recombination at telomeres, Microbial Cell, vol.2, issue.9, pp.308-321, 2015.

N. Grandin, C. Damon, and M. Charbonneau, Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination, The EMBO Journal, vol.20, issue.21, pp.6127-6139, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00077620

B. Garvik, M. Carson, and L. Hartwell, Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint., Molecular and Cellular Biology, vol.15, issue.11, pp.6128-6138, 1995.

M. Larrivée and R. J. Wellinger, Telomerase- and capping-independent yeast survivors with alternate telomere states, Nature Cell Biology, vol.8, issue.7, pp.741-747, 2006.

M. K. Zubko and D. Lydall, Linear chromosome maintenance in the absence of essential telomere-capping proteins, Nature Cell Biology, vol.8, issue.7, pp.734-740, 2006.

D. Jain, A. K. Hebden, T. M. Nakamura, K. M. Miller, and J. P. Cooper, HAATI survivors replace canonical telomeres with blocks of generic heterochromatin, Nature, vol.467, issue.7312, pp.223-227, 2010.

O. Calvo, N. Grandin, A. Jordán-pla, E. Miñambres, N. González-polo et al., The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription, Nucleic Acids Res, vol.47, pp.6250-6268, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02115731

M. Lisby, T. Teixeira, E. Gilson, and V. Géli, The fate of irreparable DNA double-strand breaks and eroded telomeres at the nuclear periphery, Nucleus, vol.1, issue.2, pp.158-161, 2010.
URL : https://hal.archives-ouvertes.fr/ensl-00817044

Z. Ding, C. J. Wu, M. Jaskelioff, E. Ivanova, M. Kost-alimova et al., Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases, Cell, vol.148, issue.5, pp.896-907, 2012.

E. J. Louis, The chromosome ends ofSaccharomyces cerevisiae, Yeast, vol.11, issue.16, pp.1553-1573, 1995.