Fibroblast growth factor 21 is elevated 609 in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine 610 secretion of human abdominal subcutaneous adipocytes, Mol Metab, vol.4, p.612, 2015. ,
Effect of endurance 613 training on skeletal muscle myokine expression in obese men: identification of apelin as a 614 novel myokine, Compr 616 Physiol, vol.38, p.17, 2012. ,
Bruun JM. Diet and exercise reduce low-grade inflammation and macrophage infiltration in 621 adipose tissue but not in skeletal muscle in severely obese subjects, AJP Endocrinol Metab, vol.55, pp.207-224, 2006. ,
, , p.627
Fatty acid-inducible ANGPTL4 governs lipid 629 metabolic response to exercise, Proc Natl Acad Sci U S A, vol.111, pp.1043-52, 2014. ,
Kersten 631 S. Pronounced Effects of Acute Endurance Exercise on Gene Expression in Resting and 632 Exercising Human Skeletal Muscle, PLoS One, vol.7, p.634, 2012. ,
The diagnosis and management of nonalcoholic fatty liver disease: Practice 635 guidance from the American Association for the Study of Liver Diseases, Hepatology, vol.67, p.23, 2018. ,
, , p.638
Circulating 641 Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes 642 and Correlates With Muscle and Hepatic Insulin Resistance, Diabetes Care, vol.48, p.25, 2009. ,
The worldwide epidemiology of type 2 diabetes mellitus-644 present and future perspectives, Nat Rev Endocrinol, vol.8, p.26, 2011. ,
Hepatic 646 Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic 647 Mice, Diabetes, vol.66, p.650, 2017. ,
, Nonalcoholic Fatty Liver Disease, Diabetes Metab J, vol.37, p.28, 2013.
, , p.652
, , p.653
HSP72 protects against obesity-induced insulin resistance ,
, Proc Natl Acad Sci U S A, vol.105, pp.1739-1783, 2008.
Effect of weight 661 loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese 662 subjects, TW, Bemben M, Kerksick 664 CM. Acute Loading and Aging Effects on Myostatin Pathway Biomarkers in Human, vol.149, p.666, 2008. ,
, Med Sci, vol.66, p.33, 2011.
Bhattacharya 668 S. NF-?B mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte 669 function effecting insulin resistance, J Appl Physiol, vol.429, pp.1381-1388, 2009. ,
Myokines in insulin resistance and type 2 diabetes ,
Lifelong 676 exercise, but not short-term high-intensity interval training, increases GDF11, a marker of 677 successful aging: a preliminary investigation, Diabetologia, vol.57, p.679, 2014. ,
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity ,
, Proc Natl Acad Sci, vol.106, p.682, 2009.
Secher 688 NH, Pedersen BK. Glucose ingestion attenuates the exercise-induced increase in circulating 689 heat shock protein 72 and heat shock protein 60 in humans, Cell Stress Chaperones, vol.125, pp.390-396, 2004. ,
,
Exercise induces hepatosplanchnic release of heat shock protein 72 in humans, J Physiol, vol.544, p.695, 2002. ,
A critical role for ChREBP-mediated FGF21 696 secretion in hepatic fructose metabolism, Mol Metab, vol.6, p.43, 2017. ,
Modulating fibroblast 698 growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction, Physiol Nutr Metab, vol.699, pp.1054-62, 2012. ,
, , p.701
Fibroblast growth factor 21 and exercise-induced hepatic 702 mitochondrial adaptations, Am J Physiol Gastrointest Liver Physiol, vol.310, pp.832-875, 2016. ,
Francois ME, Little JP. Effectiveness and safety of high-intensity interval training in patients 707 with type 2 diabetes, Am J Physiol Endocrinol Metab, vol.24, pp.333-340, 2010. ,
, , vol.715
,
Metabolic crosstalk between fatty pancreas and fatty liver: effects on local 717 inflammation and insulin secretion, Diabetologia, vol.60, p.50, 2017. ,
,
, Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance, Nature, vol.720, p.51, 2018.
Follistatin induces muscle 722 hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin ,
Ahsg-fetuin blocks the metabolic arm of insulin action 725 through its interaction with the 95-kD ?-subunit of the insulin receptor, Am J Physiol Metab, vol.297, p.53, 2009. ,
Angiopoietin-like 4 (Angptl4) Protein 728 Is a Physiological Mediator of Intracellular Lipolysis in Murine Adipocytes, J Biol Chem, vol.287, p.54, 2012. ,
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis ,
, Fibrogenesis Tissue Repair, vol.3, p.21, 2010.
Exercise and the Regulation of Endocrine Hormones, Progress in 733 molecular biology and translational science, pp.293-311, 2015. ,
, , p.735
, , p.736
Hepatokine ?1-Microglobulin Signaling Exacerbates Inflammation and 737 Disturbs Fibrotic Repair in Mouse Myocardial Infarction, Sci Rep, vol.8, p.57, 2018. ,
, , p.739
Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That 740 Follistatin Is a Contraction-Induced Hepatokine, Endocrinology, vol.152, p.58, 2011. ,
, , p.742
Plasma follistatin is elevated in patients with type 2 diabetes: 743 relationship to hyperglycemia, hyperinsulinemia, and systemic low-grade inflammation ,
, Diabetes Metab Res Rev, vol.29, pp.463-472, 2013.
, , p.746
Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in 747 humans, Mol Metab, vol.4, p.60, 2015. ,
Exercise-Induced 749 Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and ,
, Diabetes. J. Clin. Endocrinol. Metab, 2016.
, , p.752
Circulating Follistatin Is Liver-753 Derived and Regulated by the Glucagon-to-Insulin Ratio, J Clin Endocrinol Metab, vol.101, p.62, 2016. ,
, , p.756
Activin E Controls Energy Homeostasis in Both Brown and White Adipose 758 Tissues as a Hepatokine, Cell Rep, vol.25, pp.1193-1203, 2018. ,
760 Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients 761 with type 2 diabetes: A meta-analysis of randomized controlled trials, Metabolism, vol.63, p.64, 2014. ,
, , p.764
Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in 765 the liver of mice is related to plasma glucose levels after acute exercise, Diabetologia, vol.53, p.65, 2010. ,
Acute 768 regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single 769 bout of treadmill exercise, J Physiol, vol.5871, p.66, 2009. ,
Effects of elastic band resistance training and nutritional 772 supplementation on muscle quality and circulating muscle growth and degradation factors of 773 institutionalized elderly women: the Vienna Active Ageing Study (VAAS), Eur J Appl Physiol, vol.774, pp.885-897, 2016. ,
, , p.776
A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance 777 by AMPK-dependent and JNK-dependent inhibition of LECT2 expression, Biochem Pharmacol, vol.778, pp.782-1286, 2015. ,
, , p.784
, , p.785
,
Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing 787 VEGF resistance in vascular endothelial cells, Diabetologia, vol.57, p.789, 2014. ,
Association of fetuin-a with incident diabetes mellitus in 790 community-living older adults: the cardiovascular health study, Circulation, vol.125, pp.3805-3810, 2008. ,
LeBrasseur 795 NK, Walsh K. Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic 796 Parameters in Obese Mice, Cell Metab, vol.7, pp.159-172, 2008. ,
Loss of 798 angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity 799 from glucose intolerance partly via the gut microbiota, Diabetologia, vol.61, pp.1-12, 2018. ,
The impact of liver fat vs 801 visceral fat in determining categories of prediabetes, Diabetologia, vol.53, p.75, 2010. ,
Exercise training 803 attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-804 obesity in mice, Brain Behav Immun, vol.26, pp.931-941, 2012. ,
Exercise training inhibits inflammation in 806 adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic 807 switching from M1 to M2 macrophages in high-fat-diet-induced obese mice, Exerc Immunol, vol.808, p.77, 2010. ,
A systematic review and meta-analysis of 810 interval training versus moderate-intensity continuous training on body adiposity, Obes Rev, vol.811, p.78, 2017. ,
Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via 814 elevated free fatty acids, Kharitonenkov A, Adams AC. Inventing new medicines: The FGF21 story, vol.29, pp.221-229, 2009. ,
FGF-21 as a novel metabolic regulator, J 820 Clin Invest, vol.115, p.81, 2005. ,
Acute Exercise Induces FGF21 Expression 822 in Mice and in Healthy Humans, PLoS One, vol.8, 2013. ,
, , p.824
Angiopoietin-Like Protein 4 828 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics, J 829 Clin Endocrinol Metab, vol.21, pp.2332-2339, 2015. ,
Short-Term High-Intensity Interval Training on Body Composition 831 and Blood Glucose in Overweight and Obese Young Women, J Diabetes Res, vol.2016, p.85, 2016. ,
, , p.833
Transgenic angiopoietin-like (angptl)4 834 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride 835 metabolism, Hum Reprod Update, vol.146, pp.529-541, 2002. ,
, , p.839
Tissue-specific expression of betaKlotho and fibroblast 840 growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21, J 841 Biol Chem, vol.282, p.2013, 2007. ,
Kim 846 KS. An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by 847 enhancing hepatic mitochondrial function, Am J Transl Res, vol.8, p.90, 2016. ,
, , p.849
Interaction between plasma fetuin-A and free 850 fatty acids predicts changes in insulin sensitivity in response to long-term exercise, Physiol Rep, vol.851, issue.5, p.91, 2017. ,
,
, Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients 854 and are correlated with hepatic triglyceride, J Hepatol, vol.53, pp.934-974, 2010.
Elevated RBP4 plasma levels were 856 associated with diabetic retinopathy in type 2 diabetes, vol.857, p.93 ,
Retinoic acid receptor ? stimulates hepatic induction 858 of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy 859 homeostasis in mice, J Biol Chem, vol.288, pp.10490-504, 2013. ,
, , p.861
Angptl4 upregulates cholesterol synthesis in liver via 862 inhibition of LPL-and HL-dependent hepatic cholesterol uptake, Arterioscler Thromb Vasc Biol, vol.863, p.95, 2007. ,
Reduction in the Incidence of Type 2 Diabetes With Lifestyle Intervention or 865 Metformin, N Engl J Med, vol.100, pp.130-134, 2012. ,
Differential expression of insulin receptor tyrosine 867 kinase inhibitor (fetuin) gene in a model of diet-induced obesity, Life Sci, vol.63, p.97, 1998. ,
, , p.869
Richter 872 EA, Kiens B. Circulating FGF21 in humans is potently induced by short term overfeeding of 873 carbohydrates, J Appl Physiol, vol.121, pp.22-29, 2016. ,
, , p.875
Fetuin-A is linked to improved glucose tolerance after short-term 876 exercise training in non-alcoholic fatty liver disease, J Appl Physiol, vol.115, pp.988-994, 2013. ,
Exercise-induced lowering of fetuin-A may 878 increase hepatic insulin sensitivity, Med Sci Sports Exerc, vol.46, pp.2085-2090, 2014. ,
Circulating FGF21 is liver derived and enhances glucose uptake during 881 refeeding and overfeeding, Diabetes, vol.63, pp.4057-63, 2014. ,
, , p.883
Skeletal muscle-specific overexpression of heat 884 shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not 885 alter whole body metabolism, Diabetes Obes Metab, vol.20, pp.1928-1936, 2018. ,
, , p.887
Direct effects of FGF21 on glucose uptake in human 888 skeletal muscle: implications for type 2 diabetes and obesity, Diabetes Metab Res Rev, vol.27, pp.889-286, 2011. ,
Plasma 891 fetuin-A and phosphofetuin-A (Ser312) responses to a single or short-term repeated bout of 892 exercise in obese and normal-weight individuals (1028.2), FASEB J, vol.28, 1028. ,
?2-894 HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin 895 receptor, Mol Cell Endocrinol, vol.164, pp.87-98, 2000. ,
Fetuin-null mice are 897 protected against obesity and insulin resistance associated with aging, Biochem Biophys Res, vol.898, pp.437-443, 2006. ,
Improved insulin sensitivity and resistance to weight gain 901 in mice null for the Ahsg gene, Diabetes, vol.51, pp.2450-2458, 2002. ,
, , p.904
Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired 905 Glucose Metabolism Cell Metabolism Resource Fetuin B Is a Secreted Hepatocyte Factor 906 Linking Steatosis to Impaired Glucose Metabolism, Cell Metab, vol.22, pp.1078-1089, 2015. ,
Hepatokines: linking nonalcoholic fatty liver disease and insulin 908 resistance, Nat Rev Endocrinol, vol.13, pp.509-520, 2017. ,
, , p.910
, , p.911
, , p.912
A Liver-Derived Secretory Protein, p.913 ,
Causes Insulin Resistance, Cell Metab, vol.12, pp.483-495, 2010. ,
, , p.916
Takamura 917 T. Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice 918 through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle ,
, Nat Med, vol.23, pp.508-516, 2017.
RBP4 Activates Antigen-921 Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance, Cell 922 Metab, vol.19, pp.512-526, 2014. ,
Causality between non-alcoholic fatty liver 924 disease and risk of cardiovascular disease and type 2 diabetes: A meta-analysis with bias 925 analysis, Liver Int, 2018. ,
,
, Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and 928 FGF21 in humans, JCI Insight, vol.3, 2018.
Identification of a novel FGF, FGF-21, 930 preferentially expressed in the liver, Biochim Biophys Acta, vol.1492, pp.203-209, 2000. ,
, , p.932
Regulation of angiopoietin-like 933 protein 4 production during and after exercise, Physiol Rep, vol.2, 2014. ,
Nutrition and Physical 935 Activity in Nonalcoholic Fatty Liver Disease, J Diabetes Res, p.4597246, 2016. ,
Evidence that interleukin-6 is produced 937 in human skeletal muscle during prolonged running, J Physiol, vol.508, pp.949-953, 1998. ,
Serum fetuin-A concentrations are 939 elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes ,
, Clin Endocrinol (Oxf), vol.75, pp.450-455, 2011.
,
, Impaired Glucose Tolerance with or without Nonalcoholic Fatty Liver Disease, But Not 943 Impaired Fasting Glucose, J Clin Endocrinol Metab, vol.97, pp.4717-4723, 2012.
, , p.945
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced 946 insulin resistance, Nat Med, vol.18, pp.1279-85, 2012. ,
Biomarkers of insulin sensitivity and insulin resistance: Past, 948 present and future, Crit Rev Clin Lab Sci, vol.52, pp.180-190, 2015. ,
Muscle as a secretory organ, Compr Physiol, vol.3, pp.1337-62, 2013. ,
Muscles, exercise and obesity: skeletal muscle as a secretory 951 organ, Nat Rev Endocrinol, vol.8, pp.457-465, 2012. ,
, , p.953
The hepatokines fetuin-A and fetuin-B are 954 upregulated in the state of hepatic steatosis and may differently impact on glucose 955 homeostasis in humans, Am J Physiol Metab, vol.314, pp.266-273, 2018. ,
, , p.957
, , p.958
Expression 959 Atlas update-an integrated database of gene and protein expression in humans, animals and 960 plants, Nucleic Acids Res, vol.44, pp.746-752, 2016. ,
Toll-like 962 receptor expression and response to specific stimulation in adipocytes and preadipocytes: on 963 the role of fat in inflammation, Ann N Y Acad Sci, vol.1072, pp.407-416, 2006. ,
Activin A and 965 follistatin in patients with nonalcoholic fatty liver disease, Metabolism, vol.65, pp.1550-1558, 2016. ,
, , p.967
Anti-inflammatory effects of exercise 968 training in adipose tissue do not require FGF21, J Endocrinol, vol.235, pp.97-109, 2017. ,
The effects of aerobic exercises and 25(OH) D 970 supplementation on GLP1 and DPP4 level in type II diabetic patients, Int J Prev Med, vol.8, p.56, 2017. ,
, Nonalcoholic fatty liver disease a systematic review, JAMA -J. Am. Med. Assoc, p.131, 2015.
, , p.975
Serum angiopoietin-like 4 protein levels and 976 expression in adipose tissue are inversely correlated with obesity in monozygotic twins, J Lipid 977 Res, vol.52, pp.1575-1582, 2011. ,
Resistance training increases SHBG in 979 overweight/obese, young men, Metabolism, vol.62, pp.725-733, 2013. ,
Inhibition of 981 myostatin with emphasis on follistatin as a therapy for muscle disease, Muscle Nerve, vol.39, pp.283-982, 2009. ,
,
, Preventive roles of swimming exercise and pioglitazone treatment on hepatic dysfunction in a 985 rat model of metabolic syndrome, Can J Physiol Pharmacol, vol.92, pp.162-170, 2014.
, , p.987
Inhibition of protein kinase C? prevents hepatic insulin resistance in nonalcoholic 988 fatty liver disease, J Clin Invest, vol.117, pp.739-745, 2007. ,
, , p.990
The influence of adiposity and acute exercise on 991 circulating hepatokines in normal weight and overweight/obese men, Appl. Physiol. Nutr ,
, , 2017.
Fetuin A promotes lipotoxicity in ? cells 994 through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity, Mol Cell 995 Endocrinol, vol.412, pp.1-11, 2015. ,
TLR4 links innate immunity and fatty 997 acid-induced insulin resistance, J Clin Invest, vol.116, pp.3015-3025, 2006. ,
, , p.999
Primary structure of the human follistatin precursor and its genomic 1000 organization, Proc Natl Acad Sci U S A, vol.85, pp.4218-4240, 1988. ,
Effect of physical 1002 training on liver expression of activin A and follistatin in a nonalcoholic fatty liver disease 1003 model in rats, Brazilian J Med Biol Res = Rev Bras Pesqui medicas e Biol, vol.47, pp.746-52, 2014. ,
Novel insights in SHBG 1005 regulation and clinical implications, Trends Endocrinol Metab, vol.26, pp.376-383, 2015. ,
Attenuated fibroblast 1007 growth factor 21 response to acute aerobic exercise in obese individuals, Biochem Biophys Res Commun, vol.25, pp.739-745, 1008. ,
1012 Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine 1013 kinase level, Mol Endocrinol, vol.7, pp.1445-1455, 1993. ,
, Fritsche 1015 A, Haring H-U. Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via 1016
, Peroxisome Proliferator-Activated Receptor (PPAR)-and Is of Metabolic Relevance in 1017 Humans, Diabetes, vol.58, pp.579-589, 2009.
Fibroblast Growth Factor 21-1019 Metabolic Role in Mice and Men, Endocr Rev, vol.38, pp.468-488, 2017. ,
Production of 1021 interleukin-6 in contracting human skeletal muscles can account for the exercise-induced 1022 increase in plasma interleukin-6, J Physiol, vol.529, pp.237-279, 2000. ,
The role of hepatokines in metabolism, Nat Rev Endocrinol, vol.9, pp.144-152, 1024. ,
Circulating fetuin-A and free fatty acids interact to predict insulin 1026 resistance in humans, Nat Med, vol.19, pp.394-395, 2013. ,
Non-alcoholic fatty liver disease: causes, diagnosis, 1028 cardiometabolic consequences, and treatment strategies, Lancet Diabetes Endocrinol, vol.0, 2018. ,
, , 1030.
Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin 1031 resistance and fat accumulation in the liver in humans, Diabetes Care, vol.29, pp.853-860, 2006. ,
, , p.1033
Identification and characterization of metabolically benign obesity in 1034 humans, Arch Intern Med, vol.168, pp.1609-1616, 2008. ,
Therapeutic Approaches to Nonalcoholic 1036 Fatty Liver Disease: Exercise Intervention and Related Mechanisms, Front Endocrinol, vol.1037, p.588, 2018. ,
High glucose induces 1039 transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway, J 1040 Atheroscler Thromb, vol.16, pp.448-56, 2009. ,
Fibroblast growth factor 21 1042 (FGF21) in human cerebrospinal fluid: Relationship with plasma FGF21 and body adiposity, Diabetes, vol.60, pp.2758-2762, 1043. ,
,
, Cardiorespiratory fitness and visceral fat are key determinants of serum fibroblast growth 1046 factor 21 concentration in Japanese men, J Clin Endocrinol Metab, vol.99, pp.1877-84, 2014.
Endurance Exercise Reduces Hepatic Fat 1048 Content and Serum Fibroblast Growth Factor 21 Levels in Elderly Men, J Clin Endocrinol Metab, vol.1049, pp.191-199, 2016. ,
Acute exercise 1051 increases fibroblast growth factor 21 in metabolic organs and circulation, Physiol Rep, vol.4, pp.426-1052, 2016. ,
Inactivating hepatic follistatin alleviates hyperglycemia, Nat. Med, 1055. ,
Lifestyle interventions for the treatment of non-alcoholic fatty 1057 liver disease in adults: A systematic review, J. Hepatol, vol.56, pp.255-266, 2012. ,
Fetuin-A: a novel link between obesity and related 1059 complications, Int J Obes, vol.39, pp.734-741, 2015. ,
Increased activin bioavailability 1061 enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice, Endocrinology, vol.154, pp.2025-2058, 1062. ,
Angiopoietin-like 1064 protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-1065 fat-diet mice, Mol Med Rep, vol.14, pp.3293-3300, 2016. ,
The ever-expanding myokinome: discovery challenges and 1067 therapeutic implications, Nat Rev Drug Discov, vol.15, pp.719-729, 2016. ,
Nonalcoholic fatty liver disease: a challenge for pediatricians, Int J Obes, vol.1069, pp.1451-1467, 2010. ,
The role of 1071 Hepassocin in the development of non-alcoholic fatty liver disease, J Hepatol, vol.59, pp.1065-1072, 1072. ,
A novel 1074 hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 1075 diabetes, Diabetologia, vol.59, pp.1732-1774, 2016. ,
Retinol binding protein 4 stimulates hepatic 1077 sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome 1078 proliferator-activated receptor-? coactivator 1?-dependent pathway, Hepatology, vol.58, pp.564-1079, 2013. ,
Mapping the molecular 1081 signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi, Mol Metab, vol.1082, issue.20, pp.128-137, 2018. ,
Lam 1084 KSL. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but 1085 induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Acad Sci, vol.102, pp.6086-6091, 1086. ,
Fibroblast Growth Factor 1089 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity 1090 in Diet-Induced Obese Mice, Diabetes, vol.58, pp.250-259, 2009. ,
Circulating 1092 fibroblast growth factor 21 levels are closely associated with hepatic fat content: A cross-1093 sectional study, PLoS One, vol.6, p.24895, 2011. ,
1095 Effects of a three-month combined exercise programme on fibroblast growth factor 21 and 1096 fetuin-A levels and arterial stiffness in obese women, Clin Endocrinol (Oxf), vol.75, pp.464-469, 2011. ,
, , p.1098
Serum fetuin A/alpha2HS-glycoprotein levels in patients with 1099 non-alcoholic fatty liver disease: relation with liver fibrosis, Ann Clin Biochem, vol.47, pp.549-553, 1100. ,
, , p.1102
A 1103 Complex Role of Activin A in Non-Alcoholic Fatty Liver Disease, Am J Gastroenterol, vol.104, pp.2196-1104, 2009. ,
Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids 1107 in Humans, Clin Chem, vol.57, pp.691-700, 2011. ,
, , p.1109
,
Hepatic regulation of VLDL receptor by PPAR?/? and FGF21 modulates non-1111 alcoholic fatty liver disease, Mol Metab, vol.8, pp.117-131, 2018. ,
Serum FGF21 levels are increased in obesity and are independently 1114 associated with the metabolic syndrome in humans, Diabetes, vol.57, pp.1246-53, 2008. ,
,
, Overcoming Insulin Insufficiency by Forced Follistatin Expression in ?-cells of db/db Mice, Mol 1117 Ther, vol.23, pp.866-874, 2015.
Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through 1120 Degradation of Fetuin-A, Diabetes, vol.67, pp.818-830, 2018. ,