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[¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models

Abstract : Background: Melanin-targeting radiotracers are interesting tools for imaging and treatment of pigmented melanoma metastases. However, variation of the pigment concentration may alter the efficiency of such targeting. Objectives: A clear assessment of both tumor melanin status and dosimetry are therefore prerequisites for internal radiotherapy of disseminated melanoma. Materials & methods: The melanin tracer ICF01012 was labelled with iodine-123 for melanoma imaging in pigmented murine B16F0 and human SK-Mel 3 melanomas. Results: In vivo imaging showed that the uptake of [(123)I]ICF01012 to melanomas correlated significantly with melanin content. Schedule treatment of 3 × 25 MBq [(131)I]ICF01012 significantly reduced SK-Mel 3 tumor growth and significantly increased the median survival in treated mice. For this protocol, the calculated delivered dose was 53.2 Gy. Conclusion: Radio-iodinated ICF01012 is a good candidate for both imaging and therapeutic purposes for patients with metastatic pigmented melanomas.
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https://hal.uca.fr/hal-02193351
Contributor : Lydia Maigne Connect in order to contact the contributor
Submitted on : Monday, March 21, 2022 - 10:05:04 AM
Last modification on : Tuesday, August 2, 2022 - 4:36:26 AM

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Claire Viallard, Yann Perrot, Zied Boudhraa, Elodie Jouberton, Elisabeth Miot-Noirault, et al.. [¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models. European Journal of Dermatology, John Libbey Eurotext, 2015, 25 (1), pp.29-35. ⟨10.1684/ejd.2014.2481⟩. ⟨hal-02193351⟩

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