A. Dervaux and X. Laqueille, Cannabis : usage et dépendence, Press Med, vol.41, pp.1233-1273, 2012.

R. Doll and R. Peto, Mortality in relation to smoking: 20 years' observations on male British doctors, Br Med J, vol.25, pp.1525-1561, 1976.

R. Doll and R. Peto, Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers, J Epidemiol Community Health, vol.32, pp.303-316, 1978.

F. Carriot and A. J. Sasco, Cannabis et cancer. Rev Epidemiol Sante Publique, vol.48, pp.473-83, 2000.

E. Quoix, Les nouveautés épidémiologiques du cancer bronchique : les non-fumeurs, les femmes, les fumeurs de cannabis, Rev Mal Respir, vol.24, pp.6-10, 2007.

T. Urban, Manifestations respiratoires liées à l'inhalation de fumée de cannabis, Rev Mal Respir, vol.25, pp.1338-1378, 2008.

C. Brambilla and M. Colonna, Cannabis: the next villain on the lung cancer battlefield?, Eur Respir J, vol.31, pp.227-235, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00332711

D. P. Tashkin, Smoked marijuana as a cause of lung injury, Monaldi Arch Chest Dis, vol.63, pp.93-110, 2005.

W. Hall and L. Degenhardt, Adverse health effects of non-medical cannabis use, Lancet, vol.374, pp.1383-91, 2009.

, Rapport mondial sur les drogues 2010. Résumé analytique, p.31, 2010.

, Rapport annuel 2012. État du phénomène de la drogue en Europe, Observatoire européen des drogues et des toxicomanies, p.116, 2012.

F. Beck, R. Guignard, and J. B. Richard, Les niveaux d'usage des drogues en France en 2010, Tendances, vol.76, issue.8, 2012.

K. S. Sridhar, R. Jr, W. A. Weatherby, and N. L. , Possible role of marijuana smoking as a carcinogen in the development of lung cancer at a young age, J Psychoactive Drugs, vol.26, pp.285-293, 1994.

F. M. Taylor-3rd, Marijuana as a potential respiratory tract carcinogen: a retrospective analysis of a community hospital population, South Med J, vol.81, pp.1213-1219, 1988.

B. Lebeau and C. Génot, Carcinome bronchique muco-épidermoïde chez un fumeur de cannabis âgé de 22 ans, Press Med, vol.34, pp.1229-1261, 2005.
DOI : 10.1016/s0755-4982(05)84161-2

J. P. Khothadia, S. Chhabra, and A. Marcus, Anterior mediastinal mass in a young marijuana smoker: a rare case of small-cell lung cancer, Case Rep Med, p.754231, 2012.

M. Hsairi, N. Achour, and B. Zouari, Facteurs étiolo-giques du cancer bronchique primitif en Tunisie, Tunis Med, vol.71, pp.265-273, 1993.

N. Voirin, J. Berthiller, and V. Benhaïm-luzon, Risk of lung cancer and past use of cannabis in Tunisia, J Thorac Oncol, vol.1, pp.577-586, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00428043

J. Berthiller, K. Straif, and M. Boniol, Cannabis smoking and risk of lung cancer in men: a pooled analysis of three studies in Maghreb, J Thorac Oncol, vol.3, pp.1398-403, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00428254

A. J. Sasco, R. M. Merrill, and I. Dari, A case-control study of lung cancer in Casablanca, Morocco. Cancer Causes Control, vol.13, pp.609-625, 2002.

S. Sidney, Q. Jr, C. P. Friedman, and G. D. , Marijuana use and cancer incidence (California, United States), Cancer Causes Control, vol.8, pp.722-730, 1997.

M. Hashibe, H. Morgenstern, and Y. Cui, Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study, Cancer Epidemiol Biomarkers Prev, vol.15, pp.1829-1863, 2006.

B. Han, J. C. Gfroerer, and J. D. Colliver, Associations between duration of illicit drug use and health conditions; results from the 2005-2007 national surveys on drug use and health, Ann Epidemiol, vol.20, pp.289-97, 2010.

S. Aldington, M. Harwood, and B. Cox, Cannabis use and risk of lung cancer: a case-control study, Eur Respir J, vol.31, pp.280-286, 2008.

M. Hashibe, K. Straif, and D. P. Tashkin, Epidemiologic review of marijuana use and cancer risk, Alcohol, vol.35, pp.265-75, 2005.

R. Mehra, B. A. Moore, and K. Crothers, The association between marijuana smoking and lung cancer: a systematic review, Arch Intern Med, vol.166, pp.1359-67, 2006.

G. W. Martin, D. A. Wilkinson, and B. M. Kapur, Validation of selfreported cannabis use by urine analysis, Addict Behav, vol.13, pp.147-50, 1988.

C. Leuchtenberger and R. Leuchtenberger, The effects of naturally occurring metabolites (L-cysteine, vitamin C) on cultured human cells exposed to smoke of tobacco or marijuana cigarettes, Cytometry, vol.5, pp.396-402, 1984.

G. Murison, C. B. Chubb, and S. Maeda, Cannabinoids induce incomplete maturation of cultured human leukemia cells, Proc Natl Acad Sci U S A, vol.84, pp.5414-5422, 1987.

M. D. Srivastava, B. I. Srivastava, and B. Brouhard, Delta 9-tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells, Immunopharmacology, vol.40, pp.179-85, 1998.

T. A. Sarafian, D. P. Tashkin, and M. D. Roth, Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis, Toxicol Appl Pharmacol, vol.174, pp.264-72, 2001.
DOI : 10.1006/taap.2001.9224

T. A. Sarafian, S. Kouyoumjian, and F. Khoshaghideh, Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics, Am J Physiol Lung Cell Mol Physiol, vol.284, pp.298-306, 2003.
DOI : 10.1152/ajplung.00157.2002

S. Hart, O. M. Fischer, and A. Ullrich, Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor, Cancer Res, vol.15, pp.1943-50, 2004.

M. Yuan, S. M. Kiertscher, and Q. Cheng, Delta 9-tetrahydrocannabinol regulates TH1/TH2 cytokine balance in activated human T cello, J Neuroimmunol, vol.133, pp.124-155, 2002.

L. X. Zhu, S. Sharma, and M. Stolina, 9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway, J Immunol, vol.165, pp.373-80, 2000.

E. Chiesara, R. Cutrufello, and R. Rizzi, Chromosome damage in heroin-marijuana and marijuana addicts, Arch Toxicol Suppl, vol.6, pp.128-158, 1983.

M. M. Ammenheuser, A. B. Berenson, and A. E. Babiak, Frequencies of HPRT mutant lymphocytes in marijuana smoking mothers and their newborns, Mutat Res, vol.17, pp.55-64, 1998.

S. H. Barsky, M. D. Roth, and E. C. Kleerup, Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco, J Natl Cancer Inst, vol.90, pp.1198-205, 1998.

M. D. Roth, A. Arora, and S. H. Barsky, Airway inflammation in yung marijuana and tobacco smokers, Am J Respir Crit Care Med, vol.157, pp.928-965, 1998.

A. E. Munson, L. S. Harris, and M. A. Friedman, Antineoplastic activity of cannabinoids, J Natl Cancer Inst, vol.55, pp.597-602, 1975.

I. Galve-roperh, C. Sanchez, and M. L. Cortés, Antitumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation, Nat Med, vol.6, pp.313-322, 2000.

C. Sanchez, M. L. De-caballos, G. Del-pulgar, and T. , Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoïd receptor, Cancer Res, vol.61, pp.5784-5793, 2001.

M. Guzman, Cannabinoids: potential anticancer agents, Nat Rev Cancer, vol.3, pp.745-55, 2003.

M. Bifulco, C. Laezza, and S. Pisanti, Cannabinoids and cancer: pros and cons of an antitumour strategy, Br J Pharmacol, vol.148, pp.123-158, 2006.

W. Hall, M. Christie, and D. Currow, Cannabinoids and cancer: causation, remediation, and palliation, Lancet Oncol, vol.6, pp.35-42, 2005.

M. Novotny, M. L. Lee, and K. D. Bartle, A possible chemical basis for the higher mutagenicity of marijuana smoke as compared to tobacco smoke, Experientia, vol.15, pp.280-282, 1976.

S. Cohen, Adverse effects of marijuana: selected issues, Ann N Y Acad Sci, vol.362, pp.119-143, 1981.

M. Underner, T. Urban, and J. Perriot, Usage du cannabis et retentissement fonctionnel respiratoire, Rev Mal Respir, vol.30, pp.272-85, 2013.

T. C. Wu, D. P. Tashkin, and B. Djahed, Pulmonary hazards of smoking marijuana as compared with tobacco, N Engl J Med, vol.318, pp.347-51, 1988.

D. P. Tashkin, F. Gliederer, and J. Rose, CO and delta 9-THC delivery from the 1st and 2nd halves of a marijuana cigarette, Pharmacol Biochem Behav, vol.40, pp.657-61, 1991.

D. P. Tashkin, A. H. Coulson, and V. A. Clark, Respiratory symptoms and lung function in habitual heavy smokers of marijuana alone, smokers of marijuana and tobacco, smokers of tobacco alone, and non-smokers, Am Rev Respir Dis, vol.135, pp.209-225, 1987.

D. P. Tashkin, M. S. Simmons, and D. L. Sherrill, Heavy habitual marijuana smoking does not cause an accelerated decline in FEV1 with age, Am J Respir Crit Care Med, vol.155, pp.141-149, 1997.

D. P. Tashkin, F. Gliederer, and J. Rose, Effects of varying marijuana smoking profile on deposition of tar and absorption of CO and delta 9-THC, Pharmacol Biochem Behav, vol.40, pp.651-657, 1991.

S. Adlington, M. Williams, and M. Nowitz, Effects of cannabis on pulmonary structure, function and symptons, Thorax, vol.62, pp.1058-63, 2007.

R. Melamede, Harm-reduction -The cannabis paradox, Harm Reduc J, vol.22, p.17, 2005.

E. Quoix and E. Lemarié, Épidémiologie du cancer bronchique primitive : aspects classiques et nouveautés, Rev Mal Respir, vol.28, pp.1048-58, 2011.

D. Gieringer, J. Saint-laurent, and S. Goodrich, Cannabis vaporize combines delivery of THC with effective suppression of pyrolytic compounds, J Cannabis Ther, vol.4, pp.7-27, 2004.

D. Moore, P. Aveyard, and M. Connock, Effectiveness and safety of nicotine replacement therapy assisted reduction to stop smoking systematic review and meta-analysis, BMJ, vol.338, p.1024, 2009.

L. Dawkins, J. Turner, and A. Roberts, Vaping'' profils and preferences: an online survey of electronic cigarette users, Addiction, vol.108, pp.1115-1140, 2013.

J. Perriot, Sevrage des fumeurs de tabac et de cannabis : quand et comment le pneumologue doit-il « passer la main, Rev Mal Respir, vol.25, pp.1358-60, 2008.
DOI : 10.1016/s0761-8425(08)75110-6

L. Karila, A. Petit, and R. Zarmdini, Consommation de tabac et troubles liés à l'usage de substances illicites : que devrionsnous faire ?, Press Med, vol.42, pp.795-805, 2013.
DOI : 10.1016/j.lpm.2012.11.015