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Course of residual symptoms according to the duration of euthymia in remitted bipolar patients

Abstract : Objective: Although many studies showed the negative impact of residual symptoms on the course of bipolar disorder (BD), there is a need to examine potential differences in residual symptoms according to the duration of euthymia in remitted BD patients. Method: This was a large cross‐sectional study of 525 euthymic BD out‐patients. A multivariate analysis of covariance was conducted to compare depressive and manic residual symptoms, sleep disturbances and cognitive complaints among three patient groups on the basis of duration of euthymia (A. 6 months to <1 year; B. 1 year to <3 years; C. 3 years to ≤5 years). Results: A significant difference between the three groups was found in residual symptoms [Pillai's Trace: F(8942) = 4.659, P < 0.001]. Tukey post hoc analysis indicated that patients from Group C presented lower residual depressive symptoms, higher sleep quality and better perceived cognitive performance compared with Group A. Group B also presented better sleep and cognitive outcomes than Group A. In addition, Group C showed the lowest incidence of functional impairment. Conclusion: This study suggests that the intensity of residual symptoms and functional impairment in remitted BD patients is negatively related to the duration of euthymia.
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https://hal.uca.fr/hal-02158504
Contributor : de Chazeron Ingrid <>
Submitted on : Tuesday, June 18, 2019 - 10:34:09 AM
Last modification on : Friday, July 17, 2020 - 9:30:04 AM

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L. Samalin, M. Reinares, I. de Chazeron, C. Torrent, C. M. Bonnin, et al.. Course of residual symptoms according to the duration of euthymia in remitted bipolar patients. Acta Psychiatrica Scandinavica, Wiley, 2016, 134 (1), pp.57-64. ⟨10.1111/acps.12568⟩. ⟨hal-02158504⟩

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