, World Health Organisation. The Global Burden of Disease, Update, 2004.

G. M. Macqueen, L. T. Young, and R. T. Joffe, A review of psychosocial outcome in patients with bipolar disorder, Acta Psychiatr Scand, vol.103, pp.163-170, 2001.

J. Sanchez-moreno, A. Martinez-aran, R. Tabares-seisdedos, C. Torrent, E. Vieta et al., Functioning and disability in bipolar disorder: an extensive review, Psychother Psychosom, vol.78, pp.285-297, 2009.

B. Arts, N. Jabben, L. Krabbendam, and J. Van-os, Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives, Psychol Med, vol.38, pp.771-785, 2008.

T. O. Bas, C. A. Poyraz, A. Bas, B. C. Poyraz, and M. Tosun, The impact of cognitive impairment, neurological soft signs and subdepressive symptoms on functional outcome in bipolar disorder, J Affect Disord, vol.174, pp.336-341, 2015.

C. M. Bonnin, A. Martinez-aran, and C. Torrent, Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study, J Affect Disord, vol.121, pp.156-160, 2010.

S. Dittmann, K. Hennig-fast, and S. Gerber, Cognitive functioning in euthymic bipolar I and bipolar II patients, Bipolar Disord, vol.10, pp.877-887, 2008.

M. C. Mann-wrobel, J. T. Carreno, and D. Dickinson, Meta-analysis of neuropsychological functioning in euthymic bipolar disorder: an update and investigation of moderator variables, Bipolar Disord, vol.13, pp.334-342, 2011.

A. Martinez-ar-an, E. Vieta, and F. Colom, Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome, Bipolar Disord, vol.6, pp.224-232, 2004.

D. J. Martino, E. Marengo, and A. Igoa, Neurocognitive and symptomatic predictors of functional outcome in bipolar disorders: a prospective 1 year follow-up study, J Affect Disord, vol.116, pp.37-42, 2009.

E. Mora, M. J. Portella, I. Forcada, E. Vieta, and M. Mur, Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study, Psychol Med, vol.43, pp.1187-1196, 2013.

R. D. Pattanayak, R. Sagar, and M. Mehta, Neuropsychological performance in euthymic Indian patients with bipolar disorder type I: correlation between quality of life and global functioning, Psychiatry Clin Neurosci, vol.66, pp.553-563, 2012.

B. Sole, C. M. Bonnin, and C. Torrent, Neurocognitive impairment and psychosocial functioning in bipolar II disorder, Acta Psychiatr Scand, vol.125, pp.309-317, 2012.

I. J. Torres, V. G. Boudreau, and L. N. Yatham, Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis, Acta Psychiatr Scand, vol.116, issue.s434, pp.17-26, 2007.

A. P. Wingo, P. D. Harvey, and R. J. Baldessarini, Neurocognitive impairment in bipolar disorder patients: functional implications, Bipolar Disord, vol.11, pp.113-125, 2009.

M. S. Bauer, G. F. Kirk, C. Gavin, and W. O. Williford, Determinants of functional outcome and healthcare costs in bipolar disorder: a high-intensity follow-up study, J Affect Disord, vol.65, pp.231-241, 2001.

L. B. Marangell, E. B. Dennehy, and S. Miyahara, The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD, J Affect Disord, vol.114, pp.58-67, 2009.

A. R. Rosa, M. Reinares, and E. E. Michalak, Functional impairment and disability across mood states in bipolar disorder, Value Health, vol.13, pp.984-988, 2010.

A. P. Wingo, R. J. Baldessarini, M. T. Compton, and P. D. Harvey, Correlates of recovery of social functioning in types I and II bipolar disorder patients, Psychiatry Res, vol.177, pp.131-134, 2010.

L. L. Altshuler, R. M. Post, and D. O. Black, Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study, J Clin Psychiatry, vol.67, pp.1551-1560, 2006.

A. Fagiolini, D. J. Kupfer, A. Masalehdan, J. A. Scott, P. R. Houck et al., Functional impairment in the remission phase of bipolar disorder, Bipolar Disord, vol.7, pp.281-285, 2005.

L. Samalin, P. M. Llorca, and B. Giordana, Residual symptoms and functional performance in a large sample of euthymic bipolar patients in France (the OPTHYMUM study), J Affect Disord, vol.159, pp.94-102, 2014.

E. M. Boland and L. B. Alloy, Sleep disturbance and cognitive deficits in bipolar disorder: toward an integrated examination of disorder maintenance and functional impairment, Clin Psychol Rev, vol.33, pp.33-44, 2013.

S. Grover, A. Ghosh, S. Sarkar, S. Chakrabarti, and A. Avasthi, Sexual dysfunction in clinically stable patients with bipolar disorder receiving lithium, J Clin Psychopharmacol, vol.34, pp.475-482, 2014.

A. G. Harvey, D. A. Schmidt, A. Scarna, C. N. Semler, and G. M. Goodwin, Sleep-related functioning in euthymic patients with bipolar disorder, patients with insomnia, and subjects without sleep problems, Am J Psychiatry, vol.162, pp.50-57, 2005.

L. D. Hawke, S. V. Parikh, and E. E. Michalak, Stigma and bipolar disorder: a review of the literature, J Affect Disord, vol.150, pp.181-191, 2013.

M. Pinho, M. Sehmbi, and L. E. Cudney, The association between biological rhythms, depression, and functioning in bipolar disorder: a large multi-center study, Acta Psychiatr Scand, vol.133, pp.102-108, 2015.

L. Samalin, F. Bellivier, and B. Giordana, Patients' perspectives on residual symptoms in bipolar disorder: a focus group study, J Nerv Ment Dis, vol.202, pp.550-555, 2014.

G. H. Vazquez, F. Kapczinski, and P. V. Magalhaes, Stigma and functioning in patients with bipolar disorder, J Affect Disord, vol.130, pp.323-327, 2011.

M. Tohen, E. Frank, and C. L. Bowden, The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders, Bipolar Disord, vol.11, pp.453-473, 2009.

R. C. Young, J. T. Biggs, V. E. Ziegler, and D. A. Meyer, A rating scale for mania: reliability, validity and sensitivity, Br J Psychiatry, vol.133, pp.429-435, 1978.
DOI : 10.1192/bjp.133.5.429

M. Berk, G. S. Malhi, and C. Cahill, The Bipolar Depression Rating Scale (BDRS): its development, validation and utility, Bipolar Disord, vol.9, pp.571-579, 2007.
DOI : 10.1111/j.1399-5618.2007.00536.x

S. A. Strejilevich, D. J. Martino, and A. Murru, Mood instability and functional recovery in bipolar disorders, Acta Psychiatr Scand, vol.128, pp.194-202, 2013.
DOI : 10.1111/acps.12065

M. Tohen, C. A. Zarate, and J. Hennen, The McLeanHarvard First-Episode Mania Study: prediction of recovery and first recurrence, Am J Psychiatry, vol.160, pp.2099-2107, 2003.

M. Berk, F. Ng, and W. V. Wang, The empirical redefinition of the psychometric criteria for remission in bipolar disorder, J Affect Disord, vol.106, pp.153-158, 2008.

C. Henry, M. Bailara, K. Poinsot, R. Falissard, and B. , Construction and validation of a dimensional scale for mood disorders: multidimensional assessment of thymic states (MAThyS), Encephale, vol.33, pp.768-774, 2007.

T. Atzeni, C. Henry, and I. Minois, From inhibition to activation, from emotional hyporeactivity to emotional hyperreactivity: two pathways to discriminate mood in bipolar disorders, Psychiatry Res, vol.209, pp.50-54, 2013.

D. J. Buysse, T. H. Monk, S. R. Berman, and D. J. Kupfer, The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research, Psychiatry Res, vol.28, pp.193-213, 1989.

C. A. Mcgahuey, A. J. Gelenberg, and C. A. Laukes, The Arizona Sexual Experience Scale (ASEX): reliability and validity, J Sex Marital Ther, vol.26, pp.25-40, 2000.

M. Briki, E. Haffen, and J. Monnin, Sexual dysfunction and depression: validity of a French version of the ASEX scale, Encephale, vol.40, pp.114-122, 2014.

D. Claire, A. Raust, D. Fouques, A. Barbato, B. Etain et al., Validation of the French version of the functioning assessment short test (FAST) in patients with bipolar disorder. A study from the french bipolar expert centers network, Int Clin Psychopharmacol, vol.28, p.62, 2012.

A. R. Rosa, J. Sanchez-moreno, and A. Martinez-aran, Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder, Clin Pract Epidemiol Ment Health, vol.3, p.5, 2007.

R. M. Mickey and S. Greenland, The impact of confounder selection criteria on effect estimation, Am J Epidemiol, vol.129, pp.125-137, 1989.

G. W. Sun, T. L. Shook, and G. L. Kay, Inappropriate use of bivariable analysis to screen risk factors for use in multivariable analysis, J Clin Epidemiol, vol.49, pp.907-916, 1996.

A. R. Rosa, C. M. Bonnin, L. Mazzarini, B. Amann, F. P. Kapczinski et al., Clinical predictors of interpersonal functioning in patients with bipolar disorder, Rev Psiquiatr Salud Ment, vol.2, pp.83-88, 2009.

G. E. Simon, E. J. Ludman, J. Un?-utzer, B. H. Operskalski, and M. S. Bauer, Severity of mood symptoms and work productivity in people treated for bipolar disorder, Bipolar Disord, vol.10, pp.718-725, 2008.

M. Mur, M. J. Portella, A. Martinez-aran, J. Pifarre, and E. Vieta, Influence of clinical and neuropsychological variables on the psychosocial and occupational outcome of remitted bipolar patients, Psychopathology, vol.42, pp.148-156, 2009.

R. Elgie and P. L. Morselli, Social functioning in bipolar patients: the perception and perspective of patients, relatives and advocacy organizations -a review, Bipolar Disord, vol.9, pp.144-157, 2007.

E. S. Thome, A. A. Dargel, and F. M. Migliavacca, Stigma experiences in bipolar patients: the impact upon functioning, J Psychiatr Ment Health Nurs, vol.19, pp.665-671, 2012.

C. L-opez-jaramillo, J. Lopera-v-asquez, and A. Gallo, Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence, Bipolar Disord, vol.12, pp.557-567, 2010.

C. Boudebesse and C. Henry, Emotional hyper-reactivity and sleep disturbances in remitted patients with bipolar disorders, Encephale, vol.38, issue.4, pp.173-178, 2012.

M. 'bailara, K. Demotes-mainard, J. Swendsen, J. Mathieu, F. Leboyer et al., Emotional hyper-reactivity in normothymic bipolar patients, Bipolar Disord, vol.11, pp.63-69, 2009.

H. P. Blumberg, N. H. Donegan, and C. A. Sanislow, Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder, Psychopharmacology, vol.183, pp.308-313, 2005.

L. C. Foland-ross, P. M. Thompson, and C. A. Sugar, Threedimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithium, Psychiatry Res, vol.211, pp.195-201, 2013.

J. Savitz, A. C. Nugent, and W. Bogers, Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication. Neuroimage2010, vol.49, pp.2966-2976

M. Bonierbale, C. Lancon, and J. Tignol, The ELIXIR study: evaluation of sexual dysfunction in 4557 depressed patients in France, Curr Med Res Opin, vol.19, pp.114-124, 2003.

I. Pacchiarotti, A. Murru, and G. D. Kotzalidis, Hyperprolactinemia and medications for bipolar disorder: Systematic review of a neglected issue in clinical practice, Eur Neuropsychopharmacol, vol.25, pp.1045-1059, 2015.

E. Vieta, The bipolar maze: a roadmap through translational psychopathology, Acta Psychiatr Scand, vol.129, pp.323-327, 2014.
DOI : 10.1111/acps.12270

G. Schumann, E. B. Binder, and A. Holte, Stratified medicine for mental disorders, Eur Neuropsychopharmacol, vol.24, pp.5-50, 2014.
DOI : 10.1016/j.euroneuro.2013.09.010
URL : https://doi.org/10.1016/j.euroneuro.2013.09.010

E. Vieta, Personalised medicine applied to mental health: Precision psychiatry, Rev Psiquiatr Salud Ment, vol.8, pp.117-118, 2015.
DOI : 10.1016/j.rpsmen.2015.03.007

C. Torrent, M. Bonnin-cdel, and A. Martinez-aran, Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study, Am J Psychiatry, vol.170, pp.852-859, 2013.

S. V. Parikh, L. D. Hawke, and V. Velyvis, Combined treatment: impact of optimal psychotherapy and medication in bipolar disorder, Bipolar Disord, vol.17, pp.86-96, 2015.

R. Belzeaux, N. Correard, and L. Boyer, Depressive residual symptoms are associated with lower adherence to medication in bipolar patients without substance use disorder: results from the FACE-BD cohort, J Affect Disord, vol.151, pp.1009-1015, 2013.

L. L. Judd, P. J. Schettler, and H. S. Akiskal, Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence, Arch Gen Psychiatry, vol.65, pp.386-394, 2008.
DOI : 10.1001/archpsyc.65.4.386
URL : https://jamanetwork.com/journals/jamapsychiatry/articlepdf/482677/yoa70104_386_394.pdf

M. Bonnin, A. Gonzalez-pinto, and B. Sole, Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder, J Affect Disord, vol.160, pp.50-54, 2014.

M. J. Van-der-werf-eldering, H. Burger, N. Jabben, E. A. Holthausen, A. Aleman et al., Is the lack of association between cognitive complaints and objective cognitive functioning in patients with bipolar disorder moderated by depressive symptoms?, J Affect Disord, vol.130, pp.306-311, 2011.

A. Martinez-aran, E. Vieta, and F. Colom, Do cognitive complaints in euthymic bipolar patients reflect objective cognitive impairment?, Psychother Psychosom, vol.74, pp.295-302, 2005.