W. H. Organization, Fact sheet: Obesity and Overweight, 2016.

N. Esser, S. Legrand-poels, J. Piette, A. J. Scheen, and N. Paquot, Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes, Diabetes Res Clin Pract, vol.105, p.24798950, 2014.

S. S. Pereira and J. I. Alvarez-leite, Low-Grade Inflammation, Obesity, and Diabetes, Curr Obes Rep, vol.3, p.26626919, 2014.

B. L. Wajchenberg, Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome, Endocr Rev, vol.21, p.11133069, 2000.

A. Wronska and Z. Kmiec, Structural and biochemical characteristics of various white adipose tissue depots, Acta Physiol Oxf, vol.205, p.22226221, 2012.

J. Després and I. Lemieux, Abdominal obesity and metabolic syndrome, Nature, vol.444, p.17167477, 2006.

A. Everard and P. D. Cani, Diabetes, obesity and gut microbiota, Best Pract Res Clin Gastroenterol, vol.27, p.23768554, 2013.

W. Tang, T. Kitai, and S. L. Hazen, Gut Microbiota in Cardiovascular Health and Disease, Circ Res, vol.120, p.28360349, 2017.

P. J. Turnbaugh, R. E. Ley, M. A. Mahowald, V. Magrini, E. R. Mardis et al., An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, vol.444, p.17183312, 2006.

M. J. Claesson, I. B. Jeffery, S. Conde, S. E. Power, E. M. O'connor et al., Gut microbiota composition correlates with diet and health in the elderly, Nature, vol.488, pp.178-184, 2012.

E. F. Murphy, P. D. Cotter, S. Healy, T. M. Marques, O. O'sullivan et al., Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models, Gut, vol.59, p.20926643, 2010.

E. S. Chambers, D. J. Morrison, and G. Frost, Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?, Proc Nutr Soc, vol.74, p.25497601, 2015.

I. Kaji, S. Karaki, and A. Kuwahara, Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release, Digestion, vol.89, p.24458110, 2014.

Z. Gao, J. Yin, J. Zhang, R. E. Ward, R. J. Martin et al., Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice, Diabetes, vol.58, p.19366864, 2009.

A. Nakajima, A. Nakatani, S. Hasegawa, J. Irie, K. Ozawa et al., The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages, PloS One, vol.12, p.28692672, 2017.

P. D. Cani, J. Amar, M. A. Iglesias, M. Poggi, C. Knauf et al., Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, vol.56, p.17456850, 2007.

L. Hersoug, P. Møller, and S. Loft, Gut microbiota-derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity, Obes Rev Off J Int Assoc Study Obes, vol.17, p.26712364, 2016.

D. J. Johns, J. Hartmann-boyce, S. A. Jebb, and P. Aveyard, Diet or exercise interventions vs combined behavioral weight management programs: a systematic review and meta-analysis of direct comparisons, J Acad Nutr Diet, vol.114, p.25257365, 2014.

K. Shaw, H. Gennat, P. O'rourke, D. Mar, and C. , Exercise for overweight or obesity, Cochrane Database Syst Rev, vol.003817, p.17054187, 2006.

T. Wu, X. Gao, M. Chen, and R. M. Van-dam, Long-term effectiveness of diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis, Obes Rev, vol.10, p.19175510, 2009.

S. H. Boutcher, High-intensity intermittent exercise and fat loss, J Obes, p.21113312, 2011.

F. Maillard, B. Pereira, and N. Boisseau, Effect of High-Intensity Interval Training on Total, Abdominal and Visceral Fat Mass: A Meta-Analysis, Sports Med Auckl NZ, vol.48, p.29127602, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01923052

J. M. Allen, L. J. Mailing, G. M. Niemiro, R. Moore, M. D. Cook et al., Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans, Med Sci Sports Exerc, p.29166320, 2017.

E. V. Lamoureux, S. A. Grandy, and M. Langille, Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome. mSystems, vol.2, p.28845459, 2017.

J. E. Lambert, J. P. Myslicki, M. R. Bomhof, D. D. Belke, J. Shearer et al., Exercise training modifies gut microbiota in normal and diabetic mice, Appl Physiol Nutr Metab Physiol Appl Nutr Metab, vol.40, p.25962839, 2015.

B. A. Petriz, A. P. Castro, J. A. Almeida, C. P. Gomes, G. R. Fernandes et al., Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats, BMC Genomics, vol.15, p.24952588, 2014.

S. S. Kang, P. R. Jeraldo, A. Kurti, M. Miller, M. D. Cook et al., Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition. Mol Neurodegener, vol.9, p.25217888, 2014.

Z. Liu, H. Liu, H. Zhou, Q. Zhan, W. Lai et al., Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice, Front Microbiol, vol.8, p.28919891, 2017.

W. Liu, T. Wang, F. Zhou, Y. Wang, J. Xing et al., Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-? activity, Biochem Biophys Res Commun, vol.459, p.25701789, 2015.

C. C. Evans, K. J. Lepard, J. W. Kwak, M. C. Stancukas, S. Laskowski et al., Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity, PloS One, vol.9, p.24670791, 2014.

A. Mika, W. Van-treuren, A. González, J. J. Herrera, R. Knight et al., Exercise is More Effective at Altering Gut Microbial Composition and Producing Stable Changes in Lean Mass in Juvenile versus Adult Male F344 Rats, PloS One, vol.10, p.26016739, 2015.

R. B. Batacan, M. J. Duncan, V. J. Dalbo, P. S. Tucker, and A. S. Fenning, Effects of high-intensity interval training on cardiometabolic health: a systematic review and meta-analysis of intervention studies, Br J Sports Med, vol.51, p.27797726, 2017.

E. Denou, K. Marcinko, M. G. Surette, G. R. Steinberg, and J. D. Schertzer, High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity, Am J Physiol Endocrinol Metab, vol.310, p.27117007, 2016.

L. Metz, M. Vermaelen, K. Lambert, C. Broca, P. Sirvent et al., Endurance training increases lactate transport in male Zucker fa/fa rats, Biochem Biophys Res Commun, vol.331, p.15883022, 2005.

G. Kapravelou, R. Martínez, A. M. Andrade, E. Nebot, D. Camiletti-moirón et al., Aerobic interval exercise improves parameters of nonalcoholic fatty liver disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats, Appl Physiol Nutr Metab Physiol Appl Nutr Metab, vol.40, p.26509584, 2015.

P. M. Haram, O. J. Kemi, S. J. Lee, M. Ø. Bendheim, Q. Y. Al-share et al., Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity, Cardiovasc Res, vol.81, p.19047339, 2009.

D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher et al., Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, vol.28, p.3899825, 1985.

R. C. Edgar, UPARSE: highly accurate OTU sequences from microbial amplicon reads, Nat Methods, vol.10, p.23955772, 2013.

J. G. Caporaso, J. Kuczynski, J. Stombaugh, K. Bittinger, F. D. Bushman et al., QIIME allows analysis of high-throughput community sequencing data, Nat Methods, vol.7, p.20383131, 2010.

A. Lan, A. Bruneau, M. Bensaada, C. Philippe, P. Bellaud et al., Increased induction of apoptosis by Propionibacterium freudenreichii TL133 in colonic mucosal crypts of human microbiota-associated rats treated with 1,2-dimethylhydrazine, Br J Nutr, vol.100, p.18466653, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01454096

K. E. Kim, Y. S. Cho, K. S. Baek, L. Li, K. Baek et al., Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents, Korean J Pediatr, vol.59, p.27279888, 2016.

J. M. Moreno-navarrete, F. Ortega, M. Serino, E. Luche, A. Waget et al., Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance, Int J Obes, vol.36, p.22184060, 2005.

A. Gonzá-lez-sarrías, M. Romo-vaquero, R. García-villalba, A. Corté-s-martín, M. V. Selma et al., The Endotoxemia Marker Lipopolysaccharide-Binding Protein is Reduced in Overweight-Obese Subjects Consuming Pomegranate Extract by Modulating the Gut Microbiota: A Randomized Clinical Trial, Mol Nutr Food Res, p.29665619, 2018.

F. Maillard, S. Rousset, B. Pereira, A. Traore, P. De-pradel-del-amaze et al., High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes, Diabetes Metab, vol.42, p.27567125, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01608777

N. Wang, Y. Liu, Y. Ma, and D. Wen, High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice, Life Sci, vol.191, p.28843495, 2017.

Y. Shen, X. Xu, K. Yue, and G. Xu, Effect of different exercise protocols on metabolic profiles and fatty acid metabolism in skeletal muscle in high-fat diet-fed rats, Obes Silver Spring Md, vol.23, p.25864958, 2015.

M. I. Queipo-ortuño, L. M. Seoane, M. Murri, M. Pardo, J. M. Gomez-zumaquero et al., Gut Microbiota Composition in Male Rat Models under Different Nutritional Status and Physical Activity and Its Association with Serum Leptin and Ghrelin Levels, PLoS ONE, vol.8, p.23724144, 2013.

J. M. Allen, L. J. Mailing, J. Cohrs, C. Salmonson, J. Fryer et al., Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice, Gut Microbes, p.28862530, 2017.

J. R. Lee, J. E. Muckerman, A. M. Wright, D. J. Davis, T. E. Childs et al., Sex determines effect of physical activity on diet preference: Association of striatal opioids and gut microbiota composition, Behav Brain Res, vol.334, p.28743600, 2017.

C. Codling, L. O'mahony, F. Shanahan, E. Quigley, and J. R. Marchesi, A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome, Dig Dis Sci, vol.55, p.19693670, 2010.

G. Parthasarathy, J. Chen, X. Chen, N. Chia, H. M. O'connor et al., Relationship Between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients With Chronic Constipation, Gastroenterology, vol.150, p.26460205, 2016.

Y. Yang, Y. Shi, P. Wiklund, X. Tan, N. Wu et al., The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women, Nutrients, vol.9, p.28757576, 2017.

O. Cronin, O. O'sullivan, W. Barton, P. D. Cotter, M. G. Molloy et al., Gut microbiota: implications for sports and exercise medicine, Br J Sports Med, vol.51, p.28077354, 2017.

R. P. Ferraris and R. R. Vinnakota, Intestinal nutrient transport in genetically obese mice, Am J Clin Nutr, vol.62, p.7661115, 1995.

A. M. Holland, H. W. Hyatt, A. J. Smuder, K. J. Sollanek, A. B. Morton et al., Influence of endurance exercise training on antioxidant enzymes, tight junction proteins, and inflammatory markers in the rat ileum, BMC Res Notes, vol.8, p.26423686, 2015.

J. M. Bruun, C. Verdich, S. Toubro, A. Astrup, and B. Richelsen, Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men, Eur J Endocrinol, vol.148, p.12720537, 2003.

J. G. Neels, L. Badeanlou, K. D. Hester, and F. Samad, Keratinocyte-derived Chemokine in Obesity, J Biol Chem, vol.284, p.19494115, 2009.

J. Olza, C. M. Aguilera, M. Gil-campos, R. Leis, G. Bueno et al., Myeloperoxidase is an early biomarker of inflammation and cardiovascular risk in prepubertal obese children, Diabetes Care, vol.35, p.22912422, 2012.

P. D. Cani, R. Bibiloni, C. Knauf, A. Waget, A. M. Neyrinck et al., Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, vol.57, p.18305141, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00410066

M. Saghafi-asl, P. Amiri, M. Naghizadeh, S. M. Ghavami, and N. Karamzad, Association of endotoxaemia with serum free fatty acids in metabolically healthy and unhealthy abdominally obese individuals: a casecontrol study in northwest of Iran, BMJ Open, vol.7, p.28487462, 2017.

A. G. Oliveira, B. M. Carvalho, N. Tobar, E. R. Ropelle, J. R. Pauli et al., Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats, Diabetes, vol.60, p.21282367, 2011.

M. Rebuffé--scrive, B. Andersson, and L. Olbe, Bjö rntorp P. Metabolism of adipose tissue in intraabdominal depots of nonobese men and women, Metabolism, vol.38, p.2725284, 1989.

E. G. Trapp, D. J. Chisholm, and S. H. Boutcher, Metabolic response of trained and untrained women during high-intensity intermittent cycle exercise, Am J Physiol Regul Integr Comp Physiol, vol.293, p.17898114, 2007.

C. Moro, F. Pillard, D. Glisezinski, I. Harant, I. Rivière et al., Training enhances ANP lipid-mobilizing action in adipose tissue of overweight men, Med Sci Sports Exerc, vol.37, p.16015128, 2005.

B. Richterova, V. Stich, C. Moro, J. Polak, E. Klimcakova et al., Effect of endurance training on adrenergic control of lipolysis in adipose tissue of obese women, J Clin Endocrinol Metab, vol.89, p.15001629, 2004.

M. Schweiger, R. Schreiber, G. Haemmerle, A. Lass, C. Fledelius et al., Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism, J Biol Chem, vol.281, p.17074755, 2006.

R. Zimmermann, J. G. Strauss, G. Haemmerle, G. Schoiswohl, R. Birner-gruenberger et al., Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase, Science, vol.306, p.15550674, 2004.

P. G. Reeves, F. H. Nielsen, and G. C. Fahey, AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet, J Nutr, vol.123, p.8229312, 1993.

I. Cusin, F. Rohner-jeanrenaud, A. Stricker-krongrad, and B. Jeanrenaud, The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals, Diabetes, vol.45, p.8826985, 1996.

M. S. Phillips, Q. Liu, H. A. Hammond, V. Dugan, P. J. Hey et al., Leptin receptor missense mutation in the fatty Zucker rat, Nat Genet, vol.13, p.8673096, 1996.