Molecular nutrition is relatively recent research discipline that aims to decipher molecular effects of nutrition at the cellular level and identify mechanisms underlying potential impact on health, protective or deleterious. The development and the use of holistic “omics” approach in the last decade or two have revealed the complexity of action of different nutrients at the molecular level. These nutrigenomic studies have shown that nutrients can impact transcriptional and post transcriptional regulation of gene expression, by impacting expression of mRNA, non-coding RNAs (both short and long) and proteins, but also modulate epigenetic profile of the cells. The capacity of nutrients to exert these nutrigenomic effects can be related to the their ability to bind to cell signaling proteins, modulate their activity and consequently that of transcription factors. The feature article gives a rapid overview of molecular mechanisms impacted by different nutrients.