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Effects of tracheal occlusion with retinoic acid administration on normal lung development

Abstract : Tracheal occlusion (TO) is an investigational therapy for severe congenital diaphragmatic hernia that decreases pulmonary hypoplasia, but sustained TO also induces deficient surfactant synthesis. Intramuscular maternal administration of retinoic acid (RA) in a surgical rabbit model of congenital diaphragmatic hernia showed a beneficial effect on lung maturation. We evaluated the potential of RA delivery into the trachea and studied the combined effects of TO and RA on normal lung development.
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https://hal.uca.fr/hal-01918672
Contributor : LOIC BLANCHON Connect in order to contact the contributor
Submitted on : Sunday, November 11, 2018 - 10:18:25 PM
Last modification on : Wednesday, April 6, 2022 - 5:04:02 PM

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Loïc Blanchon, Amelie Delabaere, Geoffroy Marceau, Karen Coste, Loïc Blanc, et al.. Effects of tracheal occlusion with retinoic acid administration on normal lung development. Prenatal Diagnosis, Wiley, 2017, 37 (5), pp.427 - 434. ⟨10.1002/pd.5012⟩. ⟨hal-01918672⟩

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