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Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses

Abstract : Lung hypoplasia and pulmonary arterial hypertension in congenital diaphragmatic hernia lead to a high perinatal mortality. Although sustained fetoscopic tracheal occlusion (TO) improves lung development, a major side effect is abnormal pneumocyte differentiation. This study evaluated the potential ability of intratracheal retinoic acid (RA) administration to reduce adverse effects of sustained TO in a rabbit model of diaphragmatic hernia.
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https://hal.uca.fr/hal-01918664
Contributor : LOIC BLANCHON Connect in order to contact the contributor
Submitted on : Sunday, November 11, 2018 - 10:12:04 PM
Last modification on : Tuesday, January 4, 2022 - 5:18:57 AM

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Amelie Delabaere, Loïc Blanchon, Karen Coste, Gael Clairefond, Corinne Belville, et al.. Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses. Prenatal Diagnosis, Wiley, 2018, 38 (7), pp.482 - 492. ⟨10.1002/pd.5256⟩. ⟨hal-01918664⟩

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