M. Almant, V. Moreau, J. Kovensky, J. Bouckaert, and S. G. Gouin, Clustering of Escherichia coli type-1 fimbrial adhesins by using multimeric heptyl alpha-D-mannoside probes with a carbohydrate core, Chemistry, vol.17, pp.10029-10038, 2011.

D. Alvarez-dorta, A. Sivignon, T. Chalopin, T. I. Dumych, G. Roos et al., The antiadhesive strategy in Crohn ? s disease: orally active mannosides to decolonize pathogenic Escherichia coli from the gut, Chembiochem, vol.17, pp.936-952, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02077036

N. Barnich, F. A. Carvalho, A. Glasser, C. Darcha, P. Jantscheff et al., CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease, J. Clin. Invest, vol.117, pp.1566-1574, 2007.

R. O. Bilyy, T. Shkandina, A. Tomin, L. E. Muñoz, S. Franz et al., Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles, J. Biol. Chem, vol.287, pp.496-503, 2012.

R. Bilyy, A. Tomyn, Y. Kit, A. Podhorodecki, J. Misiewicz et al., Detection of dying cells using lectin-conjugated fluorescent and luminescent nanoparticles, Materwiss. Werksttech, vol.40, pp.234-237, 2009.

J. Bouckaert, J. Mackenzie, J. L. De-paz, B. Chipwaza, D. Choudhury et al., The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of Escherichia coli pathotypes, Mol. Microbiol, vol.61, pp.1556-1568, 2006.

S. Brument, A. Sivignon, T. I. Dumych, N. Moreau, G. Roos et al., Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from crohn's disease patients, J. Med. Chem, vol.56, pp.5395-5406, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01931359

T. Chalopin, D. Alvarez-dorta, A. Sivignon, M. Caudan, T. I. Dumych et al., Second generation of thiazolylmannosides, FimH antagonists for E. coli-induced Crohn's disease, Org. Biomol. Chem, vol.14, pp.3913-3925, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02077029

B. Chassaing, A. Darfeuille-michaud, and A. Darfeuille-michaud, The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases, Gastroenterology, vol.140, pp.1720-1728, 2011.

J. Chen, K. Chen, C. Fan, C. Han, Y. Chen et al., Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry, FEBS J, vol.277, pp.3028-3038, 2010.

R. Chen, X. Jiang, D. Sun, G. Han, F. Wang et al., Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry, J. Proteome Res, vol.8, pp.651-661, 2009.

S. L. Chen, C. S. Hung, J. A. Xu, C. S. Reigstad, V. Magrini et al., Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach, Proc. Natl. Acad. Sci. U.S.A, vol.103, pp.5977-5982, 2006.

I. Ciucanu and F. Kerek, A simple and rapid method for the permethylation of carbohydrates, Carbohydr. Res, vol.131, pp.209-217, 1984.

M. S. Conover, S. Ruer, J. Taganna, V. Kalas, H. De-greve et al., Inflammation-induced adhesin-receptor interaction provides a fitness advantage to uropathogenic, E. coli during chronic infection, Cell Host Microbe, vol.20, pp.482-492, 2016.

M. P. Conte, M. Aleandri, M. Marazzato, A. L. Conte, C. Ambrosi et al., The adherent/invasive Escherichia coli strain LF82 invades and persists in human prostate cell line RWPE-1, activating a strong inflammatory response, Infect. Immun, vol.84, pp.3105-3113, 2016.

A. Darfeuille-michaud, J. Boudeau, P. Bulois, C. Neut, A. L. Glasser et al., High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease, Gastroenterology, vol.127, pp.412-421, 2004.

A. Darfeuille-michaud, C. Neut, N. Barnich, E. Lederman, P. Di-martino et al., Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease, Gastroenterology, vol.115, pp.1405-1413, 1998.

J. Erde, R. R. Loo, and J. A. Loo, Enhanced FASP (eFASP) to increase proteome coverage and sample recovery for quantitative proteomic experiments, J. Proteome Res, vol.13, pp.1885-1895, 2014.

A. Farina, J. Dumonceau, P. Antinori, I. Annessi-ramseyer, J. Frossard et al., Bile carcinoembryonic cell adhesion molecule 6 (CEAM6) as a biomarker of malignant biliary stenoses, Biochim. Biophys. Acta, vol.1844, pp.1018-1025, 2014.

A. Farina, J. Dumonceau, J. Frossard, A. Hadengue, D. F. Hochstrasser et al., Proteomic analysis of human bile from malignant biliary stenosis induced by pancreatic cancer, J. Proteome Res, vol.8, pp.159-169, 2009.

B. G. Fürnrohr, M. Stein, B. Rhodes, P. S. Chana, G. Schett et al., Reduced fluorescence versus forward scatter time-of-flight and increased peak versus integral fluorescence ratios indicate receptor clustering in flow cytometry, J. Immunol, vol.195, pp.377-385, 2015.

S. E. Geerlings, R. Meiland, E. C. Van-lith, E. C. Brouwer, W. Gaastra et al., Adherence of type 1-fimbriated Escherichia coli to uroepithelial cells: more in diabetic women than in control subjects, Diabetes Care, vol.25, pp.1405-1409, 2002.

M. Gemei, P. Mirabelli, R. Di-noto, C. Corbo, A. Iaccarino et al., CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo, Cancer, vol.119, pp.729-738, 2013.

S. A. Hefta, R. J. Paxton, and J. E. Shively, Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry, J. Biol. Chem, vol.265, pp.8618-8626, 1990.

S. J. Hultgren, S. Normark, A. , and S. N. , Chaperone-assisted assembly and molecular architecture of adhesive pili, Annu. Rev. Microbiol, vol.45, pp.383-415, 1991.

C. Ilantzis, L. Demarte, R. A. Screaton, and C. P. Stanners, Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation, Neoplasia, vol.4, pp.151-163, 2002.

K. A. Kline, S. Fälker, S. Dahlberg, S. Normark, and B. Henriques-normark, Bacterial adhesins in host-microbe interactions, Cell Host Microbe, vol.5, pp.580-592, 2009.

D. J. Klumpp, M. T. Rycyk, M. C. Chen, P. Thumbikat, S. Sengupta et al., Uropathogenic Escherichia coli induces extrinsic and intrinsic cascades to initiate urothelial apoptosis, Infect. Immun, vol.74, pp.5106-5113, 2006.

K. B. Laupland, T. Ross, J. D. Pitout, D. L. Church, and D. B. Gregson, Community-onset urinary tract infections: a population-based assessment, Infection, vol.35, pp.150-153, 2007.

J. J. Martinez, M. A. Mulvey, J. D. Schilling, J. S. Pinkner, and S. J. Hultgren, Type 1 pilus-mediated bacterial invasion of bladder epithelial cells, EMBO J, vol.19, pp.2803-2812, 2000.

C. Maueröder, R. A. Chaurio, T. Dumych, M. Podolska, M. D. Lootsik et al., A blast without power-cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses, Cell Death Differ, vol.23, pp.1016-1025, 2016.

S. Miquel, E. Peyretaillade, L. Claret, A. De-vallée, C. Dossat et al., Complete genome sequence of Crohn's diseaseassociated adherent-invasive E. coli strain LF82, PLoS ONE, vol.5, 2010.

I. U. Mysorekar, M. Isaacson-schmid, J. N. Walker, J. C. Mills, and S. J. Hultgren, Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection, Cell Host Microbe, vol.5, pp.463-475, 2009.

I. Nicoletti, G. Migliorati, M. C. Pagliacci, F. Grignani, R. et al., A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry, J. Immunol. Methods, vol.139, pp.271-279, 1991.

P. Ramachandran, P. Boontheung, Y. Xie, M. Sondej, D. T. Wong et al., Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry, J. Proteome Res, vol.5, pp.1493-1503, 2006.

C. J. Riley, K. P. Engelhardt, J. W. Saldanha, W. Qi, L. S. Cooke et al., Design and activity of a murine and humanized anti-CEACAM6 singlechain variable fragment in the treatment of pancreatic cancer, Cancer Res, vol.69, pp.1933-1940, 2009.

N. Sharma, S. Srivastava, F. Kern, W. Xian, K. G. Yeoh et al., CEACAM 6, a novel marker for the diagnosis of Barrett's esophagus, Dis. Esophagus, vol.30, pp.1-5, 2017.

T. Shkandina, M. Herrmann, and R. Bilyy, Sweet kiss of dying cell: sialidase activity on apoptotic cell is able to act toward its neighbors, Autoimmunity, vol.45, pp.574-578, 2012.

W. E. Stamm, Scientific and clinical challenges in the management of urinary tract infections, Am. J. Med, vol.113, 2002.

J. Taganna, A. R. De-boer, M. Wuhrer, and J. Bouckaert, Glycosylation changes as important factors for the susceptibility to urinary tract infection, Biochem. Soc. Trans, vol.39, pp.349-354, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00641767

M. Thaysen-andersen, V. Venkatakrishnan, I. Loke, C. Laurini, S. Diestel et al., Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum, J. Biol. Chem, vol.290, pp.8789-8802, 2015.

J. A. Thompson, F. Grunert, and W. Zimmermann, Carcinoembryonic antigen gene family: molecular biology and clinical perspectives, J. Clin. Lab. Anal, vol.5, pp.344-366, 1991.

P. Thumbikat, R. E. Berry, G. Zhou, B. K. Billips, R. E. Yaggie et al., Bacteria-induced uroplakin signaling mediates bladder response to infection, PLoS Pathog, vol.5, p.1000415, 2009.

A. Tomin, T. Dumych, Y. Tolstyak, I. Kril, I. Mahorivska et al., Desialylation of dying cells with catalytically active antibodies possessing sialidase activity facilitate their clearance by human macrophages, Clin. Exp. Immunol, vol.179, pp.17-23, 2015.

J. R. Turner, Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application, Am. J. Pathol, vol.169, pp.1901-1909, 2006.

E. Van-der-pol, A. N. Böing, P. Harrison, A. Sturk, N. et al., Classification, functions, and clinical relevance of extracellular vesicles, Pharmacol. Rev, vol.64, pp.676-705, 2012.

S. D. Weeks and J. Bouckaert, Small-angle X-ray scattering to obtain models of multivalent lectin-glycan complexes, 2014.

, Methods Mol. Biol, vol.1200, pp.511-526

A. Wellens, C. Garofalo, H. Nguyen, N. Van-gerven, R. Slattegard et al., Intervening with urinary tract infections using antiadhesives based on the crystal structure of the FimH-oligomannose-3 complex, PLoS ONE, vol.3, p.2040, 2008.

J. R. Wi´sniewskiwi´sniewski, A. Zougman, N. Nagaraj, and M. Mann, Universal sample preparation method for proteome analysis, Nat. Methods, vol.6, pp.359-362, 2009.

B. Xie, G. Zhou, S. Chan, E. Shapiro, X. Kong et al., Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia, J. Biol. Chem, vol.281, pp.14644-14653, 2006.

X. Yan, A. Sivignon, N. Yamakawa, A. Crepet, C. Travelet et al., Glycopolymers as antiadhesives of E. coli strains inducing inflammatory bowel diseases, vol.16, pp.1827-1836, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01174249

G. Zhou, W. J. Mo, P. Sebbel, G. Min, T. A. Neubert et al., Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding, J. Cell Sci, vol.114, pp.4095-4103, 2001.

, Conflict of Interest Statement: The authors declare that the research was

©. Copyright, . Dumych, . Yamakawa, . Sivignon, . Garenaux et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, 2018.