Body weight gain and deep brain stimulation - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Journal of the Neurological Sciences Année : 2011

Body weight gain and deep brain stimulation

Résumé

Deep brain stimulation (DBS) is a neurosurgical technique that has now been available for some 25 years. It is used in the treatment of various motor disorders, e.g. Parkinson's disease (PD), essential tremor and dystonia, and neuropsychiatric illnesses, e.g. obsessive-compulsive disorder and Tourette syndrome. The surgical targets of DBS include the thalamic ventralis intermedius nucleus (Vim), the globus pallidus internus (GPi) and more recently the subthalamic nucleus (STN), currently considered as the reference target in the treatment of PD. In the last ten years, most studies in PD patients have described a rapid and marked weight gain in the months following DBS of the STN. This weight gain sometimes induces obesity and can have metabolic repercussions. The physiopathological mechanisms responsible for the weight gain are multifactorial (changes in energy metabolism and eating behaviour, reduction of motor complications, etc.). This review reports current knowledge concerning weight changes in patients treated by DBS with different surgical targets. It also describes the mechanisms responsible for weight gain and the health outcome for the patients.

Dates et versions

hal-01721831 , version 1 (17-06-2019)

Identifiants

Citer

Isabelle Rieu, Philippe Derost, Miguel Ulla, Ana Marques, Bérangère Debilly, et al.. Body weight gain and deep brain stimulation. Journal of the Neurological Sciences, 2011, 310 (1-2), pp.267-270. ⟨10.1016/j.jns.2011.06.055⟩. ⟨hal-01721831⟩
323 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More