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Conscious behaviors following bilateral pallido-thalamic low frequency stimulation in patients with continuing disorders of consciousness

Abstract : Deep brain stmulaton (DBS) has been proposed to enable consciousness recovery. We studied clinical effects of bilateral pallido-thalamic low frequency stmulaton intended to overdrive neuronal actvity. Five patents were included. Primary outcome was the analysis of scores of the Coma Recovery Scale Revised (CRS-R; 0-23). Statstcal analyses used random-effects models accountng between and within patent variability due to repeated measurements. We observed statstcally signifcant improvement of CRS-R during DBS-ON versus baseline (P1, P3) and CO-On versus baseline (P3). For the 5 patents auditory, visual, motor, oromotor-verbal, communicaton subscores of CRS-R were signifcantly improved.
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https://hal.uca.fr/hal-01654638
Contributor : Jérôme Coste <>
Submitted on : Tuesday, November 20, 2018 - 11:20:27 AM
Last modification on : Wednesday, June 10, 2020 - 1:12:07 PM

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  • HAL Id : hal-01654638, version 1

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Jean-Jacques Lemaire, Anna Sontheimer, Bruno Pereira, Jérôme Coste, Sarah, D Rosenberg, et al.. Conscious behaviors following bilateral pallido-thalamic low frequency stimulation in patients with continuing disorders of consciousness. 1ère journée conjointe TGI TechMed, CHU de Clermont-Ferrand, Université Clermont Auvergne, Institut Pascal, Sep 2017, Clermont-Ferrand, France. ⟨hal-01654638⟩

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