Three-dimensional mapping of the lateral ventricles in autism

Christine Vidal 1 Rob Nicolson Jean-Yves Boire 2 Vincent Barra 3 Timothy J Devito Kiralee M Hayashi 4 Jennifer A Geaga Dick J Drost Peter C Williamson Nagalingam Rajakumar Arthur W Toga 4 Paul M Thompson 4 Timothy J. Devito Kiralee M. Hayashi 4 Jennifer A. Geaga Dick J. Drost Peter C. Williamson Arthur W. Toga 4 Paul M. Thompson 4
1 CECILLE - Centre d'Études en Civilisations Langues et Lettres Étrangères (CECILLE) - EA 4074
2 ERIM-ERI 14 - Equipe de Recherche en Signal et Imagerie Medicale
3 LIMOS - Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes
4 LONI - Laboratory of Neuro Imaging [Los Angeles]
Abstract : In this study, a computational mapping technique was used to examine the three-dimensional profile of the lateral ventricles in autism. T1-weighted three-dimensional magnetic resonance images of the brain were acquired from 20 males with autism (age: 10.1+/-3.5 years) and 22 male control subjects (age: 10.7+/-2.5 years). The lateral ventricles were delineated manually and ventricular volumes were compared between the two groups. Ventricular traces were also converted into statistical three-dimensional maps, based on anatomical surface meshes. These maps were used to visualize regional morphological differences in the thickness of the lateral ventricles between patients and controls. Although ventricular volumes measured using traditional methods did not differ significantly between groups, statistical surface maps revealed subtle, highly localized reductions in ventricular size in patients with autism in the left frontal and occipital horns. These localized reductions in the lateral ventricles may result from exaggerated brain growth early in life.
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Journal articles
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https://hal.uca.fr/hal-01622428
Contributor : Vincent Barra <>
Submitted on : Tuesday, October 24, 2017 - 1:49:33 PM
Last modification on : Monday, January 20, 2020 - 12:14:05 PM

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PRES_CLERMONT | CNRS | CECILLE | LIMOS | UNIV-LILLE

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Christine Vidal, Rob Nicolson, Jean-Yves Boire, Vincent Barra, Timothy J Devito, et al.. Three-dimensional mapping of the lateral ventricles in autism. Psychiatry Research: Neuroimaging, Elsevier, 2008, 163 (2), pp.106 - 115. ⟨10.1016/j.pscychresns.2007.11.002⟩. ⟨hal-01622428⟩

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