T. Abe, N. Ohshita, S. Sugiyo, M. Moritani, M. Kobayashi et al., Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensory nucleus: I. High intensity electrical stimulation of the trigeminal ganglion, Neuroscience, vol.133, issue.3, pp.739-786, 2005.
DOI : 10.1016/j.neuroscience.2005.03.021

H. Baba, T. Doubell, and C. Woolf, Peripheral inflammation facilitates A fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord, J Neurosci, vol.19, pp.859-67, 1999.

G. Baranauskas and A. Nistri, NMDA receptor-independent mechanisms responsible for the rate of rise of cumulative depolarization evoked by trains of dorsal root stimuli on rat spinal motoneurones, Brain Research, vol.738, issue.2, pp.349-65, 1998.
DOI : 10.1016/S0006-8993(96)00997-3

J. Baulmann, H. Spitznagel, T. Herdegen, T. Unger, and J. Culman, Tachykinin receptor inhibition and c-Fos expression in the rat brain following formalin-induced pain, Neuroscience, vol.95, issue.3, pp.813-833, 2000.
DOI : 10.1016/S0306-4522(99)00478-9

S. Begon, G. Pickering, A. Eschalier, A. Mazur, Y. Rayssiguier et al., Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats, British Journal of Pharmacology, vol.16, issue.6, pp.1227-1263, 2001.
DOI : 10.1111/j.1476-5381.1993.tb13795.x

D. Ben-nathan, D. Kobiler, S. Rzotkiewicz, S. Lustig, and Y. Katz, CNS Penetration by Noninvasive Viruses Following Inhalational Anesthetics, Annals of the New York Academy of Sciences, vol.32, issue.14, pp.944-50, 2000.
DOI : 10.1056/NEJM199210013271405

D. Bereiter, D. Bereiter, B. Tonnessen, and D. Maclean, Selective blockade of substance P or neurokinin A receptors reduces the expression of c-fos in trigeminal subnucleus caudalis after corneal stimulation in the rat, Neuroscience, vol.83, issue.2, pp.525-559, 1998.
DOI : 10.1016/S0306-4522(97)00433-8

S. Bolton, O. Shaughnessy, C. Goadsby, and P. , Properties of neurons in the trigeminal nucleus caudalis responding to noxious dural and facial stimulation, Brain Research, vol.1046, issue.1-2, pp.122-131, 2005.
DOI : 10.1016/j.brainres.2005.03.044

J. Brown, H. Liu, J. Maggio, S. Vigna, P. Mantyh et al., Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis, The Journal of Comparative Neurology, vol.52, issue.3, pp.327-371, 1995.
DOI : 10.1111/j.1476-5381.1990.tb14080.x

D. Budai and A. Larson, Role of substance P in the modulation of C-fiber-evoked responses of spinal dorsal horn neurons, Brain Research, vol.710, issue.1-2, pp.197-203, 1996.
DOI : 10.1016/0006-8993(95)01384-9

V. Chapman, J. Buritova, P. Honore, and J. Besson, Physiological contributions of neurokinin 1 receptor activation, and interactions with NMDA receptors, to inflammatory-evoked spinal c-Fos expression, J Neurophysiol, vol.76, pp.1817-1844, 1996.

V. Chapman and A. Dickenson, The effect of intrathecal administration of RP67580, a potent neurokinin 1 antagonist on nociceptive transmission in the rat spinal cord, Neuroscience Letters, vol.157, issue.2, pp.149-52, 1993.
DOI : 10.1016/0304-3940(93)90724-Y

C. Chiang, B. Hu, J. Hu, J. Dostrovsky, and B. Sessle, Central Sensitization of Nociceptive Neurons in Trigeminal Subnucleus Oralis Depends on Integrity of Subnucleus Caudalis, Journal of Neurophysiology, vol.88, issue.1, pp.256-64, 2002.
DOI : 10.1152/jn.00944.2001

R. Dallel, C. Duale, P. Luccarini, and J. Molat, Stimulus-function, wind-up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis, European Journal of Neuroscience, vol.65, issue.1, pp.31-40, 1999.
DOI : 10.1016/0006-8993(92)91084-R

R. Dallel, C. Duale, and J. Molat, Morphine administered in the substantia gelatinosa of the spinal trigeminal nucleus caudalis inhibits nociceptive activities in the spinal trigeminal nucleus oralis, J Neurosci, vol.18, pp.3529-3565, 1998.

R. Dallel, P. Luccarini, J. Molat, and A. Woda, Effects of systemic morphine on the activity of convergent neurons of spinal trigeminal nucleus oralis in the rat, European Journal of Pharmacology, vol.314, issue.1-2, pp.19-25, 1996.
DOI : 10.1016/S0014-2999(96)00480-3

C. De-felipe, J. Herrero, O. Brien, J. Palmer, J. Doyle et al., Altered nociception, analgesia and aggression in mice lacking the receptor for substance P, Nature, vol.392, pp.394-401, 1998.

R. Dubner and G. Bennett, Spinal and Trigeminal Mechanisms of Nociception, Annual Review of Neuroscience, vol.6, issue.1, pp.381-418, 1983.
DOI : 10.1146/annurev.ne.06.030183.002121

M. Hamba, H. Hisamitsu, and M. Muro, Wind-up of tooth pulp-evoked responses and its suppression in rat trigeminal caudal neurons, Brain Research Bulletin, vol.29, issue.6, pp.883-892, 1992.
DOI : 10.1016/0361-9230(92)90160-Y

J. Henry, B. Sessle, G. Lucier, and J. Hu, Effects of substance P on nociceptive and non-nociceptive trigeminal brain stem neurons, Pain, vol.8, issue.1, pp.33-45, 1980.
DOI : 10.1016/0304-3959(80)90088-3

J. Herrero, J. Laird, and J. Lopez-garcia, Wind-up of spinal cord neurones and pain sensation: much ado about something?, Progress in Neurobiology, vol.61, issue.2, pp.169-203, 2000.
DOI : 10.1016/S0301-0082(99)00051-9

R. Hill, T. Salt, and C. Pepper, A comparison of the effectiveness of intravenous morphine at attenuating the nociceptive responses of medullary dorsal horn and thalamic neurones, Life Sciences, vol.31, issue.20-21, pp.2331-2335, 1982.
DOI : 10.1016/0024-3205(82)90149-7

T. Hokfelt, A. Ljungdahl, L. Terenius, R. Elde, and G. Nilsson, Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P., Proceedings of the National Academy of Sciences, vol.74, issue.7, pp.3081-3086, 1977.
DOI : 10.1073/pnas.74.7.3081

P. Honore, P. Menning, S. Rogers, M. Nichols, A. Basbaum et al., Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states, J Neurosci, vol.19, pp.7670-7678, 1999.

J. Hu, B. Sessle, P. Raboisson, R. Dallel, and A. Woda, Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones, Pain, vol.48, issue.1, pp.53-60, 1992.
DOI : 10.1016/0304-3959(92)90131-T

J. Hu, A. Woda, and B. Sessle, Effects of pre-emptive local anaesthesia on tooth pulp deafferentation-induced neuroplastic changes in cat trigeminal brainstem neurones, Archives of Oral Biology, vol.44, issue.3, pp.287-93, 1999.
DOI : 10.1016/S0003-9969(98)00111-3

J. Hu, Response properties of nociceptive and non-nociceptive neurons in the rat?s trigeminal subnucleus caudalis (medullary dorsal horn) related to cutaneous and deep craniofacial afferent stimulation and modulation by diffuse noxious inhibitory controls, Pain, vol.41, issue.3, pp.331-376, 1990.
DOI : 10.1016/0304-3959(90)90010-B

X. Hua, C. P. Marsala, M. Yaksh, and T. , Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids, Neuroscience, vol.89, issue.2, pp.525-559, 1999.
DOI : 10.1016/S0306-4522(98)00488-6

J. Huber, K. Witt, S. Hom, R. Egleton, K. Mark et al., Inflammatory pain alters blood?brain barrier permeability and tight junctional protein expression, Am J Physiol Heart Circ Physiol, vol.280, pp.1241-1249, 2001.

S. Hunt, J. Kelly, P. Emson, J. Kimmel, R. Miller et al., An immunohistochemical study of neuronal populations containing neuropeptides or gamma-aminobutyrate within the superficial layers of the rat dorsal horn, Neuroscience, vol.10, pp.1883-98, 1981.

G. Improta and M. Broccardo, Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat???,1, Peptides, vol.21, issue.11, pp.1611-1617, 2000.
DOI : 10.1016/S0196-9781(00)00292-8

M. Jacquin, K. Semba, M. Egger, and R. Rhoades, Organization of HRP-labeled trigeminal mandibular, primary afferent neurons in the rat, The Journal of Comparative Neurology, vol.12, issue.4, pp.397-420, 1983.
DOI : 10.1001/archneurpsyc.1949.02310180035005

T. Jessell and L. Iversen, Opiate analgesics inhibit substance P release from rat trigeminal nucleus, Nature, vol.150, issue.5620, pp.549-51, 1977.
DOI : 10.1016/0006-8993(76)90370-X

M. Jung, R. Calassi, J. Maruani, M. Barnouin, J. Souilhac et al., Neuropharmacological characterization of SR 140333, a non peptide antagonist of NK1 receptors, Neuropharmacology, vol.33, issue.2, pp.167-79, 1994.
DOI : 10.1016/0028-3908(94)90004-3

S. Khasabov, S. Rogers, J. Ghilardi, C. Peters, P. Mantyh et al., Spinal neurons that possess the substance P receptor are required for the development of central sensitization, J Neurosci, vol.22, pp.9086-98, 2002.

J. Laird, R. Hargreaves, and R. Hill, Effect of RP 67580, a non-peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat, British Journal of Pharmacology, vol.49, issue.3, pp.713-721, 1993.
DOI : 10.1016/0024-3205(91)90637-Q

J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura et al., The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn, Neuroscience Research, vol.36, issue.4, pp.327-361, 2000.
DOI : 10.1016/S0168-0102(00)00095-X

Y. Li, H. Li, T. Kaneko, and N. Mizuno, Substantia gelatinosa neurons in the medullary dorsal horn: An intracellular labeling study in the rat, The Journal of Comparative Neurology, vol.62, issue.3, pp.399-412, 1999.
DOI : 10.1007/978-1-4899-0597-0

A. Light and A. Kavookjian, Morphology and ultrastructure of physiologically identified substantia gelatinosa (lamina II) neurons with axons that terminate in deeper dorsal horn laminae (III-V), The Journal of Comparative Neurology, vol.202, issue.2, pp.172-89, 1988.
DOI : 10.1113/jphysiol.1977.sp011980

X. Liu and J. Sandkuhler, Characterization of long-term potentiation of C-fiber-evoked potentials in spinal dorsal horn of adult rat: essential role of NK1 and NK2 receptors, J Neurophysiol, vol.78, pp.1973-82, 1997.

P. Luccarini, M. Henry, P. Alvarez, A. Gaydier, and R. Dallel, Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.368, issue.4, pp.320-323, 2003.
DOI : 10.1007/s00210-003-0799-z

Q. Ma and C. Woolf, Tachykinin NK1 receptor antagonist RP67580 attenuates progressive hypersensitivity of flexor reflex during experimental inflammation in rats, European Journal of Pharmacology, vol.322, issue.2-3, pp.165-71, 1997.
DOI : 10.1016/S0014-2999(97)00014-9

L. Mendell, Physiological properties of unmyelinated fiber projection to the spinal cord, Experimental Neurology, vol.16, issue.3, pp.316-348, 1966.
DOI : 10.1016/0014-4886(66)90068-9

J. Michaud, R. Alonso, C. Gueudet, M. Fournier, R. Calassi et al., receptor antagonist, on trigemino-thalamic nociceptive pathways in the rat, Fundamental & Clinical Pharmacology, vol.52, issue.1, pp.88-94, 1998.
DOI : 10.1111/j.1476-5381.1993.tb13432.x

M. Millan, Descending control of pain, Progress in Neurobiology, vol.66, issue.6, pp.355-474, 2002.
DOI : 10.1016/S0301-0082(02)00009-6

D. Mitsikostas, S. Del-rio, and M. , Receptor systems mediating c-fos expression within trigeminal nucleus caudalis in animal models of migraine, Brain Research Reviews, vol.35, issue.1, pp.20-35, 2001.
DOI : 10.1016/S0165-0173(00)00048-5

V. Morisset and F. Nagy, Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord, J Neurosci, vol.19, pp.7309-7325, 1999.

V. Morisset and F. Nagy, Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons, European Journal of Neuroscience, vol.46, issue.9, pp.3087-95, 2000.
DOI : 10.1016/0167-0115(93)90102-E

T. Nakatsuka, H. Furue, M. Yoshimura, and J. Gu, Activation of central terminal vanilloid receptor-1 receptors and alpha betamethylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord, J Neurosci, vol.22, pp.1228-1265, 2002.

T. Nakatsuka, J. Park, E. Kumamoto, T. Tamaki, and M. Yoshimura, Plastic changes in sensory inputs to rat substantia gelatinosa neurons following peripheral inflammation, Pain, vol.82, issue.1, pp.39-47, 1999.
DOI : 10.1016/S0304-3959(99)00037-8

Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat, The Journal of Comparative Neurology, vol.264, issue.2, pp.249-74, 1994.
DOI : 10.1177/29.4.6166661

V. Neugebauer, H. Schaible, F. Weiretter, and U. Freudenberger, The involvement of substance P and neurokinin-1 receptors in the responses of rat dorsal horn neurons to noxious but not to innocuous mechanical stimuli applied to the knee joint, Brain Research, vol.666, issue.2, pp.207-222, 1994.
DOI : 10.1016/0006-8993(94)90774-9

B. Oztas, S. Akgul, and F. Arslan, Influence of surgical pain stress on the blood-brain barrier permeability in rats, Life Sciences, vol.74, issue.16, pp.1973-1982, 2004.
DOI : 10.1016/j.lfs.2003.07.054

G. Paxinos and C. Watson, The rat brain in stereotaxic coordinates, 1997.

D. Price, J. Greenspan, and R. Dubner, Neurons involved in the exteroceptive function of pain, Pain, vol.106, issue.3, pp.215-224, 2003.
DOI : 10.1016/j.pain.2003.10.016

P. Raboisson, R. Dallel, P. Clavelou, B. Sessle, and A. Woda, Effects of subcutaneous formalin on the activity of trigeminal brain stem nociceptive neurones in the rat, J Neurophysiol, vol.73, pp.496-505, 1995.

R. Rhoades, N. Chiaia, P. Hess, and M. Miller, Effect of neonatal infraorbital nerve transection on substance P-and leucine enkephalin-like immunoreactivities in trigeminal subnucleus caudalis of the rat, J Neurosci, vol.8, pp.2234-2281, 1988.

L. Ritz and J. Greenspan, Morphological features of lamina V neurons receiving nociceptive input in cat sacrocaudal spinal cord, The Journal of Comparative Neurology, vol.9, issue.4, pp.440-52, 1985.
DOI : 10.1007/978-1-4757-1688-7

N. Rupniak, E. Carlson, S. Shepheard, G. Bentley, A. Williams et al., Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, Neuropharmacology, vol.45, pp.140333-608231, 2003.

M. Sabino, P. Honore, S. Rogers, D. Mach, N. Luger et al., Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain, Pain, vol.95, issue.1, pp.175-86, 2002.
DOI : 10.1016/S0304-3959(01)00397-9

A. Santos and J. Calixto, Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice, Neuropeptides, vol.31, issue.4, pp.381-390, 1997.
DOI : 10.1016/S0143-4179(97)90075-5

B. Sessle, Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates, Critical Reviews in Oral Biology & Medicine, vol.11, issue.1, pp.57-91, 2000.
DOI : 10.1016/0006-8993(96)00123-0

T. Sugimoto, Y. Fujiyoshi, C. Xiao, Y. He, and H. Ichikawa, Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat, The Journal of Comparative Neurology, vol.55, issue.3, pp.425-467, 1997.
DOI : 10.1177/00220345870660052201

R. Suzuki, S. Hunt, and A. Dickenson, The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice, Neuropharmacology, vol.45, issue.8, pp.1093-100, 2003.
DOI : 10.1016/S0028-3908(03)00281-8

R. Suzuki, S. Morcuende, M. Webber, S. Hunt, and A. Dickenson, Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways, Nature Neuroscience, vol.440, issue.12, pp.1319-1345, 2002.
DOI : 10.1002/cne.1368

M. Takemura, T. Sugimoto, and Y. Shigenaga, Difference in central projection of primary afferents innervating facial and intraoral structures in the rat, Experimental Neurology, vol.111, issue.3, pp.324-355, 1991.
DOI : 10.1016/0014-4886(91)90099-X

A. Todd, Anatomy of Primary Afferents and Projection Neurones in the Rat Spinal Dorsal Horn with Particular Emphasis on Substance P and the Neurokinin 1 Receptor, Experimental Physiology, vol.87, issue.2, pp.245-254, 2002.
DOI : 10.1113/eph8702351

D. Voisin, S. Domejean-orliaguet, M. Chalus, R. Dallel, and A. Woda, Ascending connections from the caudal part to the oral part of the spinal trigeminal nucleus in the rat, Neuroscience, vol.109, issue.1, pp.183-93, 2002.
DOI : 10.1016/S0306-4522(01)00456-0

H. Weng, H. Mansikka, R. Winchurch, S. Raja, and P. Dougherty, Sensory Processing in the Deep Spinal Dorsal Horn of Neurokinin-1 Receptor Knockout Mice, Anesthesiology, vol.94, issue.6, pp.1105-1117, 2001.
DOI : 10.1097/00000542-200106000-00027

A. Woda, O. Blanc, D. Voisin, J. Coste, J. Molat et al., Bidirectional modulation of windup by NMDA receptors in the rat spinal trigeminal nucleus, European Journal of Neuroscience, vol.62, issue.8, pp.2009-2025, 2004.
DOI : 10.1016/S0306-4522(01)00175-0

URL : https://hal.archives-ouvertes.fr/hal-01543022

J. Yip and L. Chahl, Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [Sar9,Met(O2)11]substance P, Neuroscience, vol.94, issue.2, pp.663-73, 1999.
DOI : 10.1016/S0306-4522(99)00283-3