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Nouveaux traceurs TEMP : exemple des traceurs des protéoglycanes et de la mélanine

F Cachin 1, 2 J Chezal 1 E Miot-Noirault 1 N Moins 1 P Auzeloux 1 A Vidal 1 M Bonnet-Duquennoy 1 S Boisgard 3, 1 M Filaire D Mestas 2 A Kelly 2 C Merlin 2 F Redini 4 Michel d'Incan 5, 1 J Madelmont 1 A Veyre 2 J Maublant 2
4 UMR 957
Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, CHU Nantes - Centre hospitalier universitaire de Nantes
Abstract : The majority of research program on new radiopharmaceutics turn to tracers used for positron emission tomography (PET). Only a few teams work on new non fluorine labeled tracers. However, the coming of SPECT/CT gamma cameras, the arrival of semi-conductors gamma cameras should boost the development of non-PET tracers.We exhibit in this article the experience acquired by our laboratory in the conception and design of two new non fluorine labelled compounds. The 99mTc-NTP 15-5 which binds to proteoglycans could be used for the diagnosis and staging of osteoarthritis and chondrosarcoma. The iodobenzamides, specific to the melanin, are nowadays compared to 18F-fluorodeoxyglucose in a phase III clinical trial for the diagnosis and detection of melanoma metastasis. Our last development focus on BZA heteroaromatic analogues usable for melanoma treatment.
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Submitted on : Monday, January 8, 2018 - 4:35:49 PM
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F Cachin, J Chezal, E Miot-Noirault, N Moins, P Auzeloux, et al.. Nouveaux traceurs TEMP : exemple des traceurs des protéoglycanes et de la mélanine. Médecine Nucléaire, Elsevier/Masson, 2009, 33 (3), pp.161-169. ⟨10.1016/j.mednuc.2009.01.003⟩. ⟨hal-01505284⟩



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