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Technetium-99m radiolabelling of anN-amino-alkyl-benzamide nitrido- and oxo-technetium bis(aminoethanethiol) derivative synthesis and biological results. Potential melanoma tracer agents

Abstract : N-(2-diethylaminoethyl)-4-iodobenzamide has been reported to be an excellent agent for malignant melanoma diagnosis by SPECT. To obtain a 99mTc analog, we synthesized a new bis(aminothiol) (BAT) derivative. The benzamide function was conjugated onto a nitrogen of the BAT backbone. This ligand was successfully radiolabelled with both nitrido-technetium and oxo-technetium cores. These complexes were purified by HPLC. Tumour uptake was measured in intravenously injected mice bearing the B16 murine melanoma.
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https://hal.uca.fr/hal-01494477
Contributor : Philippe Auzeloux <>
Submitted on : Monday, January 8, 2018 - 2:39:45 PM
Last modification on : Tuesday, January 9, 2018 - 1:29:39 AM

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Philippe Auzeloux, Marie-France Moreau, Janine Papon, Martine Bayle, Michèle Borel, et al.. Technetium-99m radiolabelling of anN-amino-alkyl-benzamide nitrido- and oxo-technetium bis(aminoethanethiol) derivative synthesis and biological results. Potential melanoma tracer agents. Journal of Labelled Compounds and Radiopharmaceuticals, Wiley-Blackwell, 1999, 42 (6), pp.567 - 579. ⟨10.1002/(SICI)1099-1344(199906)42:6<567::AID-JLCR217>3.0.CO;2-P⟩. ⟨hal-01494477⟩

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