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Synthesis and biodistribution of technetium-99m-labelled N-(diethylaminoethyl)benzamide via a bis(dithiocarbamate) nitridotechnetium(V) complex

Abstract : N-(2-diethylaminoethyl)-4-iodobenzamide has been reported to be an excellent agent for malignant melanoma diagnosis by SPECT. To obtain a 99mTc analogue, we synthesized a sodium N-{2-[4-(N-diethylaminoethylcarbamoyl)phenyl]ethyl}-N-methyldithiocarbamate ligand in 7 steps from methyl 4-(bromomethyl)benzoate. The corresponding nitridotechnetium complex formed by a ligand exchange method was purified and its biodistribution in mice bearing the B16 murine melanoma was determined.
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https://hal.uca.fr/hal-01494418
Contributor : Philippe Auzeloux <>
Submitted on : Monday, January 8, 2018 - 2:40:44 PM
Last modification on : Tuesday, January 9, 2018 - 1:29:41 AM

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Philippe Auzeloux, Janine Papon, Thierry Masnada, Michèle Borel, Marie-France Moreau, et al.. Synthesis and biodistribution of technetium-99m-labelled N-(diethylaminoethyl)benzamide via a bis(dithiocarbamate) nitridotechnetium(V) complex. Journal of Labelled Compounds and Radiopharmaceuticals, Wiley-Blackwell, 1999, 42 (4), pp.325 - 335. ⟨10.1002/(SICI)1099-1344(199904)42:4<325::AID-JLCR193>3.0.CO;2-J⟩. ⟨hal-01494418⟩

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