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Article Dans Une Revue Nature Communications Année : 2017

Novel genetic loci associated with hippocampal volume

Derrek P. Hibar (1, 2) , Hieab H. H. Adams (3, 2) , Neda Jahanshad (1, 2) , Ganesh Chauhan (4, 2) , Jason L. Stein (5, 2) , Edith Hofer (5, 2) , Miguel E. Renteria (6, 2) , Joshua C. Bis (7, 2) , Alejandro Arias-Vasquez (8, 9, 2) , M. Kamran Ikram (2) , Sylvane Desrivières (10, 2) , Meike W. Vernooij (2) , Lucija Abramovic (11, 2) , Saud Alhusaini (12, 13, 2) , Najaf Amin (14, 2) , Micael Andersson (15, 2) , Konstantinos Arfanakis (16, 17, 2) , Benjamin S. Aribisala (18, 19, 2) , Nicola J. Armstrong (20, 2) , Lavinia Athanasiu (21, 2) , Tomas Axelsson (22, 2) , Ashley H. Beecham (23, 2) , Alex Beiser (24, 25, 2) , Manon Bernard (26) , Susan H. Blanton (27, 2) , Marc Bohlken (11, 2) , Marco Boks (11, 2) , Janita Bralten (28, 29, 2) , Adam M. Brickman (5, 2) , Owen Carmichael (30, 2) , M. Mallar Chakravarty (31, 2) , Qiang Chen (5, 2) , Christopher Ching (5, 2) , Vincent Chouraki (32, 2, 33) , Gabriel Cuellar-Partida (6, 2) , Fabrice Crivello (34, 2) , Anouk den Braber (5, 2) , Nhat Trung Doan (2) , Stefan Ehrlich (35, 2) , Sudheer Giddaluru (21, 36, 2) , Aaron L. Goldman (37, 2) , Rebecca F. Gottesman (38, 2) , Oliver Grimm (5, 2) , Michael E. Griswold (5, 2) , Tulio Guadalupe (39, 40, 2) , Boris A. Gutman (41, 42, 2) , Johanna Hass (43, 2) , Unn K. Haukvik (21, 2) , David Hoehn (5, 2) , Avram J. Ho (44, 2) , Martine Hoogman (5, 2) , Deborah Janowitz (45, 2) , Tianye Jia (46, 2) , Kjetil N. Jørgensen (47, 2) , Nazanin Karbalai (5, 2) , Dalia Kasperaviciute (48, 49, 2) , Sungeun Kim (2) , Marieke Klein (50, 2) , Bernd Kraemer (51, 2) , Phil H. Lee (5, 2) , David C. Liewald (18, 2) , Lorna M. Lopez (2) , Michelle Luciano (52, 2) , Christine Macare (10, 2) , André F. Marquand (2) , Mar Matarin (53, 2) , Karen A. Mather (54, 2) , Manuel Mattheisen (55, 56, 57, 2) , David Mckay (2) , Yuri Milaneschi (58, 2) , Susana Muñoz Maniega (2) , Kwangsik Nho (59, 60, 2) , Allison C. Nugent (61, 2) , Paul Nyquist (62, 2) , Loes M. Olde Loohuis (2) , Jaap Oosterlaan (2) , Martina Papmeyer (2) , Lukas Pirpamer (2) , Benno Pütz (63, 2) , Adaikalavan Ramasamy (64, 2) , Jennifer S. Richards (2) , Shannon L. Risacher (59, 60, 2) , Robert Roiz-Santiañez (65, 2) , Nanda Rommelse (66, 29, 2) , Stefan Ropele (67, 2) , Emma Rose (68, 2) , Natalie A. Royle (2) , Tatjana Rundek (2) , Philipp G. Sämann (69, 2) , Arvin Saremi (2) , Claudia L. Satizabal (70, 2) , Lianne Schmaal (58, 2) , Andrew Schork (71, 72, 2) , Li Shen (73, 2) , Jean Shin (2) , Elena Shumskaya (5, 2) , Albert Smith (74, 2) , Emma Sprooten (75, 2) , Lachlan T. Strike (76, 77, 78, 2) , Alexander Teumer (2) , Diana Tordesillas-Gutierrez (2) , Roberto Toro (79, 2) , Daniah Trabzuni (80, 81, 2) , Stella Trompet (2) , Dhananjay Vaidya (2) , Jeroen van Der Grond (82, 2) , Sven van Der Lee (2) , Dennis van Der Meer (83, 2) , Marjolein M. J. van Donkelaar (28, 29, 2) , Kristel R. van Eijk (11, 2) , Theo G. M. van Erp (84, 2) , Daan van Rooij (85, 2) , Esther Walton (86, 2) , Lars Westlye (21, 87, 2) , Christophe Whelan (1, 2) , Beverly G. Windham (21, 2) , Anderson M. Winkler (2) , Katharina Wittfeld (45, 88, 2) , Girma Woldehawariat (89, 2) , Christiane Wolf (2) , Thomas Wolfers (5, 2) , Lisa R. Yanek (2) , Jingyun Yang (2) , Alex Zijdenbos (90, 2) , Marcel Zwiers (29, 2) , Ingrid Agartz (91, 2) , Laura Almasy (92, 2) , David Ames (93, 2) , Philippe Amouyel (94, 2, 33) , Ole A Andreassen (2) , Sampath Arepalli (95, 2) , Amelia A. Assareh (2) , Sandra Barral (2) , Mark Bastin (18, 2) , Diane M. Becker (2) , James T. Becker (2) , David A. Bennett (96, 2) , John Blangero (97, 98, 2) , Hans van Bokhoven (99, 2) , Dorret I. Boomsma (2) , Henry Brodaty (100, 101, 2) , Rachel M. Brouwer (102, 2) , Han G. Brunner (2) , Randy L. Buckner (103, 2) , Jan K. Buitelaar (29, 2) , Kazima B. Bulayeva (104, 2) , Wiepke Cahn (105, 2) , Vince D. Calhoun (106, 107, 2) , Dara M. Cannon (108, 2) , Gianpiero L. Cavalleri (109, 2) , Ching-Yu Cheng (110, 2) , Sven Cichon (55, 56, 111, 112, 2) , Mark Cookson (113, 2) , Aiden Corvin (114, 115, 2) , Benedicto Crespo-Facorro (65, 2) , Joanne E. Curran (2) , Michael Czisch (116, 2) , Anders M. Dale (2) , Gareth E. Davies (117, 2) , Anton J. M. de Craen (2) , Eco J. C. de Geus (2) , Philip L. de Jager (118, 119, 120, 2) , Greig I. de Zubicaray (121, 2) , Ian Deary (2) , Stéphanie Debette (122, 2) , Charles Decarli (2) , Norman Delanty (13, 123, 2) , Chantal Depondt (124, 2) , Anita Destefano (25, 2) , Allissa Dillman (125, 2) , Srdjan Djurovic (2) , Gary Donohoe (114, 108, 2) , Wayne C. Drevets (108, 2) , Ravi Duggirala (97, 2) , Thomas Dyer (97, 98, 2) , Christian Enzinger (2) , Susanne Erk (126, 2) , Thomas Espeseth (21, 87, 2) , Iryna O. Fedko (127, 2) , Guillén Fernández (128, 2) , Luigi Ferrucci (5, 2) , Simon Fisher (129, 2) , Debra A. Fleischman (17, 130, 2) , Ian Ford (131, 2) , Myriam Fornage (132, 98, 2) , Tatiana M. Foroud (133, 2) , Peter Fox (134, 2) , Clyde Francks (29, 39, 2) , Masaki Fukunaga (135, 2) , J. Raphael Gibbs (136, 2) , David C. Glahn (75, 2) , Randy L. Gollub (137, 2) , Harald H. H. Göring (138, 2) , Robert Green (139, 2) , Oliver Gruber (2) , Vilmundur Gudnason (140, 141, 2) , Sebastian Guelfi (80, 2) , Asta K. Håberg (2) , Narelle K. Hansell (52, 2) , John Hardy (2, 142) , Catharina A. Hartman (52, 2) , Ryota Hashimoto (2) , Katrin Hegenscheid (45, 2) , Andreas Heinz (2) , Stephanie Le Hellard (21, 36, 2) , Dena G. Hernandez (2) , Dirk J. Heslenfeld (45, 2) , Beng-Choon Ho (143, 2) , Pieter J. Hoekstra (144, 2) , Wolfgang Hoffmann (2) , Albert Hofman (2) , Florian Holsboer (145, 2) , Georg Homuth (146, 2) , Norbert Hosten (45, 2) , Jouke-Jan Hottenga (2) , Matthew Huentelman (147, 2) , Hilleke E. Hulshoff Pol (2) , Masashi Ikeda (2) , Clifford R. Jack Jr (2) , Mark Jenkinson (148, 2) , Robert Johnson (149, 150, 2) , Erik G. Jönsson (151, 2) , J. Wouter Jukema (2) , René S. Kahn (152, 2) , Ryota Kanai (153, 154, 2) , Iwona Kloszewska (155, 2) , David S. Knopman (156, 2) , Peter Kochunov (157, 2) , John B. Kwok (158, 2) , Stephen M. Lawrie (18, 2) , Hervé Lemaître (159, 2) , Xinmin Liu (2) , Dan L. Longo (160, 2) , Oscar L. Lopez (2) , Simon Lovestone (161, 2) , Oliver Martinez (2) , Jean-Luc Martinot (2, 162) , Venkata S. Mattay (163, 2) , Colm Mcdonald (164, 2) , Andrew Mcintosh (165, 2) , Francis J. Mcmahon (2) , Katie L. Mcmahon (166, 2) , Patrizia Mecocci (167, 2) , Ingrid Melle (91, 168, 169, 170, 2) , Andreas Meyer-Lindenberg (171, 2) , Sebastian Mohnke (172, 2) , Grant W. Montgomery (173, 76, 2) , Derek W. Morris (2) , Thomas H. Mosley (174, 2) , Thomas W. Mühleisen (55, 56, 2) , Bertram Müller-Myhsok (175, 2) , Michael A. Nalls (176, 2) , Matthias Nauck (177, 2) , Thomas E. Nichols (178, 2) , Wiro J. Niessen (179, 14, 2) , Markus M. Nöthen (180, 2) , Lars Nyberg (181, 2) , Kazutaka Ohi (182, 2) , Rene L. Olvera (183, 2) , Roel A. Ophoff (184, 2) , Massimo Pandolfo (124, 2) , Tomas Paus (185, 186, 2) , Zdenka Pausova (187, 2) , Brenda W. J. H. Penninx (173, 2) , G. Bruce Pike (5, 2) , Steven G. Potkin (188, 2) , Bruce M. Psaty (2) , Simone Reppermund (100, 2) , Marcella Rietschel (189, 190, 2) , Joshua L. Roffman (191, 2) , Nina Romanczuk-Seiferth (172, 2) , Jerome I. Rotter (192, 2) , Mina Ryten (80, 193, 2) , Ralph L. Sacco (194, 2) , Perminder S. Sachdev (2) , Andrew Saykin (59, 60, 172, 2) , Reinhold Schmidt (195, 2) , Helena Schmidt (196, 2) , Peter R. Schofield (197, 2) , Sigurdur Sigursson (5, 2) , Andrew Simmons (2) , Andrew Singleton (176, 2) , Sanjay M. Sisodiya (2) , Colin Smith (2) , Jordan W. Smoller (198, 2) , Hilkka Soininen (199, 2) , Vidar M. Steen (21, 2) , David J. Stott (2) , Jessika E. Sussmann (18, 2) , Anbupalam Thalamuthu (200, 2) , Arthur W. Toga (41, 2) , Bryan J. Traynor (201, 2) , Juan Troncoso (2) , Magda Tsolaki (202, 2) , Christophe Tzourio (203, 204, 2) , Andre G. Uitterlinden (2) , Maria C. Valdés Hernández (2) , Marcel van Der Brug (205, 2) , Aad van Der Lugt (206, 2) , Nic J. A. van Der Wee (207, 2) , Neeltje E. M. van Haren (11, 2) , Dennis van ’t Ent (2) , Marie-Jose van Tol (208, 2) , Badri N. Vardarajan (2) , Bruno Vellas (209, 2) , Dick J. Veltman (58, 2) , Henry Völzke (210, 2) , Henrik Walter (211, 172, 2) , Joanna M. Wardlaw (2) , Thomas H. Wassink (212, 2) , Michael E. Weale (213, 2) , Daneil R Weinberger (2) , Michael W. Weiner (2) , Wei Wen (2) , Eric Westman (214, 2) , Tonya White (2) , Tien Y. Wong (2) , Clinton B. Wright (215, 2) , Ronald H. Zielke (5, 2) , Alan B. Zonderman (89, 2) , Nicholas G. Martin (2) , Cornelia M. van Duijn (14, 2) , Margaret J. Wright (216, 2) , W. T. Longstreth (5, 2) , Gunter Schumann (2) , Hans J. Grabe (217, 2) , Barbara Franke (218, 2) , Lenore J. Launer (5, 2) , Sarah E. Medland (76, 2) , Sudha Seshadri (2) , Paul M. Thompson (219, 2) , M. Arfan Ikram (2)
1 David Geffen School of Medicine [Los Angeles]
2 Metacohorts Consortium
3 Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
4 INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France
5 Sans affiliation
6 QIMR Berghofer Medical Research Institute
7 University of Washington [Seattle]
8 Department of Psychiatry
9 Department of Human Genetics
10 Institute of Psychiatry, Psychology & Neuroscience, King's College London
11 University Medical Center [Utrecht]
12 Department of Neurology and Neurosurgery [Montreal]
13 Molecular and Cellular Therapeutics
14 Erasmus MC - Erasmus University Medical Center [Rotterdam]
15 Sahlgrenska University Hospital [Gothenburg]
16 Department of Biomedical Engineering
17 Rush University Medical Center [Chicago]
18 Edin. - University of Edinburgh
19 LASU - Lagos State University
20 APHM - Assistance Publique - Hôpitaux de Marseille
21 UiO - University of Oslo
22 Department of medical sciences
23 John P. Hussman Institute for Human Genomics
24 BUSM - Boston University School of Medicine
25 BU - Boston University [Boston]
26 University of Toronto
27 Genetics
28 Radboud University Medical Center [Nijmegen]
29 Donders Institute for Brain, Cognition and Behaviour
30 UCDavis-Neuro - Neurology Department, University of California, Davis
31 Douglas Mental Health University Institute
32 Université Lille Nord de France (COMUE)
33 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
34 GIN - Groupe d'imagerie neurofonctionnelle
35 MetaGenoPolis
36 Haukeland University Hospital
37 Ames Laboratory [Ames, USA]
38 Johns Hopkins University School of Medicine [Baltimore]
39 Language and Genetics Department [Nijmegen]
40 IMPRS - International Max Planck Research School for Language Sciences
41 LONI - Laboratory of Neuro Imaging [Los Angeles]
42 Department of Mathematics [UCLA]
43 Georgia Institute of Technology [Atlanta]
44 Medizinische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Germany
45 Greifswald University Hospital
46 BNU - Beijing Normal University
47 AAU - Aalborg University [Denmark]
48 UCL Institute of Neurology and Epilepsy Society
49 Department of Medicine
50 Service d'Endocrinologie [CHRU Nancy]
51 Georg-August-University = Georg-August-Universität Göttingen
52 Medstar Research Institute
53 Clinical And Experimental Epilepsy
54 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
55 Department of Genomics, Life and Brain Center
56 Institute of Human Genetics
57 Department of Biomedicine and the Centre for Integrative Sequencing
58 Department of Psychiatry
59 Indiana University School of Medicine
60 Indiana Alzheimer Disease Center
61 Institute of Food & Health, University College Dublin,
62 Department of Neurology
63 Statistical Genetics Group
64 Respiratory Epidemiology and Public Health
65 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
66 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]
67 Department of Neurology [Austria]
68 IPCM - Institut Parisien de Chimie Moléculaire
69 Max Planck Institute of Psychiatry
70 INSERM, Neuroepidemiology U708, Bordeaux, France
71 Neuro - UC San Diego - Department of Neurosciences [Univ California San Diego]
72 CogSci - UC San Diego - Department of Cognitive Sciences [Univ California San Diego]
73 Wuhan University [China]
74 Plymouth University
75 Dpt of Psychiatry [New Haven]
76 Queensland Institute of Medical Research
77 School of Psychology, University of Queensland, Brisbane 4072, Australia
78 Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia
79 CNRS - UMR3571 - Gènes, Synapses et Cognition
80 Reta Lila Weston Institute of Neurological Studies
81 Department of Genetics
82 Depts of Radiology
83 University of Twente
84 Department of Psychiatry and Human Behavior [Irvine]
85 RCMG Ghent
86 EDC - Centre épigénétique et destin cellulaire
87 Department of Psychology [Oslo]
88 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
89 NIH - National Institutes of Health [Bethesda, MD, USA]
90 Biospective [Montréal]
91 KG Jebsen Centre for Psychosis Research
92 Department of Genetics
93 Department of Psychiatry and National Ageing Research Institute
94 Université de Lille
95 Department of Clinical Genetics
96 Department of Experimental Physics
97 Texas Biomedical Research Institute [San Antonio, TX]
98 UTHealth - The University of Texas Health Science Center at Houston
99 849 Department of Human Genetics
100 Centre for Healthy Brain Ageing
101 Dementia Collaborative Research Centre
102 Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands
103 Department of Psychiatry [Boston]
104 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia
105 Department of Psychiatry
106 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]
107 The Mind Research Network
108 Human Genetics Branch
109 Division of Molecular and Cellular Therapeutics
110 NPU - Northwestern Polytechnical University [Xi'an]
111 INM-1 - Institute of Neuroscience and Medicine
112 Division of Medical Genetics
113 Cell Biology and Gene Expression Section
114 Department of Psychiatry
115 Neuropsychiatric Genetics Research Group
116 Bijvoet Center of Biomolecular Research [Utrecht]
117 York Structural Biology Laboratory, Department of Chemistry
118 HMS - Harvard Medical School [Boston]
119 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
120 Program in Translational NeuroPsychiatric Genomics,
121 School of Psychology, University of Queensland
122 Epidémiologie et Biostatistique [Bordeaux]
123 Neurology Division, Beaumont Hospital, Dublin 9, Ireland
124 Department of Neurology
125 Laboratory of Neurogenetics
126 Department of Genomics
127 Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands
128 ISM - Institut des Sciences du Mouvement Etienne Jules Marey
129 EHESS - École des hautes études en sciences sociales
130 Department of Radiology
131 Robertson Centre for Biostatistics, University of Glasgow
132 Human Genetics Center
133 Department of Medical and Molecular Genetics
134 RPI - Rensselaer Polytechnic Institute
135 Department of Physics, Okayama University
136 University of New Haven [Connecticut]
137 Athinoula A. Martinos Center for Biomedical Imaging
138 Public Health Genomics Unit
139 Department of Mathematics, University of Colorado
140 Faculty of Medicine
141 Icelandic Heart Association, Kopavogur, Iceland.
142 UCL Queen Square Institute of Neurology
143 University of Science, VNU-HCM
144 Department of Psychiatry
145 Neuronal Plasticity / Mouse Behaviour
146 Interfaculty Institute for Genetics and Functional Genomics
147 Department of Medical Genetics
148 University of Oxford
149 UF - University of Florida [Gainesville]
150 GU - Göteborgs Universitet = University of Gothenburg
151 Department of Medicine, Clinical Pharmacology Unit
152 Brain Centre Rudolf Magnus [Utrecht]
153 University of Sussex
154 Institute of Cognitive Neuroscience
155 MUL - Medical University of Łódź
156 Department of Neurology
157 Department of Psychiatry
158 School of Biomedical Sciences, Faculty of Biological Sciences
159 UCP - Université de Cergy Pontoise
160 Lymphocyte Cell Biology Unit, Laboratory of Genetics
161 Psychiatry Institute
162 UNH - Unité de Nutrition Humaine
163 Department of Health and Human Services
164 Department of Life Sciences
165 MSI - Mathematical Sciences Institute
166 Centre for Advanced Imaging
167 Institute of Gerontology and Geriatrics
168 Division of Mental Health and Addiction
169 Institute of Clinical Medicine [Oslo]
170 Division of Mental Health and Addiction
171 University Hospital Mannheim | Universitätsmedizin Mannheim
172 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
173 Genetic Epidemiology Unit
174 UMMC - University of Mississippi Medical Center
175 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
176 Laboratory of Neurogenetics
177 Institute of Clinical Chemistry and Laboratory Medicine
178 Department of Statistics [Coventry]
179 TU Delft - Delft University of Technology
180 Rheinische Friedrich-Wilhelms-Universität Bonn
181 Department of Health Science, Division of Health and Rehabilitation
182 Department of Psychiatry
183 Department of Medical and Molecular Genetics
184 Department of Psychiatry
185 UON - University of Nottingham, UK
186 MNI - McConnell Brain Imaging Centre
187 Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada
188 Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA
189 Department of Genetic Epidemiology in Psychiatry
190 Department of Psychiatry
191 Department of Psychiatry
192 Cedars-Sinai Medical Center
193 Department of Medical and Molecular Genetics
194 POLIMI - Politecnico di Milano [Milan]
195 University of Applied Sciences [Munich]
196 Dpt of Pharmacology and Personalised Medicine [Maastricht]
197 Genetics of Mental Illness and Brain Function
198 Massachusetts General Hospital [Boston]
199 University of Eastern Finland
200 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia
201 National Institute of Aging
202 3rd Department of Neurology
203 BPH - Bordeaux population health
204 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement
205 Genentech, Inc. [San Francisco]
206 Department of Radiology
207 Psychiatry and Leiden Institute for Brain and Cognition
208 LUMC - Leiden University Medical Center
209 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
210 Institute for Community Medicine
211 Berlin School of Mind and Brain [Berlin]
212 Department of Psychiatry
213 Centre for Population Health Sciences
214 Department of Neurobiology, Care Sciences and Society
215 University of Pretoria [South Africa]
216 Mizzou - University of Missouri [Columbia]
217 Department of Psychiatry and Psychotherapy
218 Donders Center for Cognitive Neuroimaging
219 USC - University of Southern California
Jean Shin
  • Fonction : Auteur
Ian Deary
  • Fonction : Auteur
Wei Wen
  • Fonction : Auteur

Résumé

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r g ¼ À 0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

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Neurosciences
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hal-01488337 , version 1 (13-03-2017)

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Derrek P. Hibar, Hieab H. H. Adams, Neda Jahanshad, Ganesh Chauhan, Jason L. Stein, et al.. Novel genetic loci associated with hippocampal volume. Nature Communications, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩. ⟨hal-01488337⟩
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