Skip to Main content Skip to Navigation
Journal articles

Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired.

Abstract : Mitochondrial DNA lesions cause numerous human diseases, and it is therefore important to identify the mechanisms whereby the mitochondrion repairs the damage. We have studied in cultured Drosophila cells the repair of bleomycin-induced double-strand breaks (DSBs) in mitochondrial DNA. Our results show that DSBs are repaired as rapidly and effectively in the mitochondria as in the nucleus. DNA repair is complete within 2h following bleomycin treatment, showing that Drosophila mitochondria have an effective system of DSB repair. The mechanism and mitochondrial proteins involved remain to be identified.
Document type :
Journal articles
Complete list of metadata

https://hal.uca.fr/hal-01063346
Contributor : Camille Meyer Connect in order to contact the contributor
Submitted on : Thursday, September 11, 2014 - 6:29:50 PM
Last modification on : Friday, December 15, 2017 - 9:18:22 AM

Links full text

Identifiers

Collections

Citation

Frédéric Morel, Monique Renoux, Philippe Lachaume, Serge Alziari. Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired.. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Elsevier, 2008, 637 (1-2), pp.111-7. ⟨10.1016/j.mrfmmm.2007.07.007⟩. ⟨hal-01063346⟩

Share

Metrics

Record views

131