One of the advantages of hadrontherapy with respect to conventional radiotherapy is the fact that the ions deposit a large quantity of their dose at the end of their path in the Bragg peak, which allows a maximization of the dose applied to the tumor and a minimization of the dose in healthy tissues. The lateral dose distribution is also quite narrow. Another advantage is the higher relative biological effectiveness. Due to the sharp falloff, one of the major issues for quality control during the treatment with ion beams is the control of the Bragg peak position and its conformation to the tumor volume. A mispositioning would either lead to an over-dosage of healthy tissue and/or an under-dosage in the target volume. Since no primary radiation is emerging from the patient during treatment, secondary radiation is used for in vivo monitoring purposes. The secondary radiation needs to have a weak interaction probability inside the patient to reach external detectors and it needs to be correlated to the primary beam dose distribution. This information on electromagnetic energy distribution (the LET) can be extracted from nuclear interactions. Several types of secondary radiations are being investigated in the LabEx PRIMES: (i) the detection of the two 511 keV gammas following a beta+ decay via a PET scanner, (ii) prompt secondary radiation following inelastic nuclear interactions, either prompt gamma rays via a collimated gamma or Compton camera, or light charged particles via second proton vertex imaging. Another quality assurance issue prior to the irradiation is under investigation in the LabEx: proton radiography and computed tomography (CT). This could improve proton therapy compared to current clinical practice since it could reduce the uncertainty of the proton therapy planning due to the lack of accuracy in the proton stopping power of tissues computed from photon CT images. We will review those different techniques under study in the frame of the WP1 of the LabEx PRIMES to setup a better online control of the beam range during therapy.