Skip to Main content Skip to Navigation
Journal articles

Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System

Abstract : The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe–simvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated. The tendency toward re-crystallization of the amorphous ezetimibe–simvastatin system, at both standard storage and elevated temperature conditions, have been studied by means of X-ray diffraction (XRD). Our investigations have revealed that simvastatin remarkably improves the physical stability of ezetimibe, despite the fact that it works as a plasticizer. Pure amorphous ezetimibe, when stored at room temperature, begins to re-crystallize after 14 days after amorphization. On the other hand, the ezetimibe-simvastatin binary mixture (at the same storage conditions) is physically stable for at least 1 year. However, the devitrification of the binary amorphous composition was observed at elevated temperature conditions (T = 373 K). Therefore, we used a third compound to hinder the re-crystallization. Finally, both the physical stability as well as viscoelastic properties of the ternary systems containing different concentrations of the latter component have been thoroughly investigated.
Complete list of metadata

https://hal.univ-lille.fr/hal-03690920
Contributor : LillOA Université de Lille Connect in order to contact the contributor
Submitted on : Tuesday, June 21, 2022 - 12:51:32 PM
Last modification on : Wednesday, June 22, 2022 - 3:36:13 AM

File

pharmaceuticals-12-00040.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Karolina Jurkiewicz, Natália Correia, Wiesław Sawicki, et al.. Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System. Pharmaceuticals, MDPI, 2019, 12 (1), pp.40. ⟨10.3390/ph12010040⟩. ⟨hal-03690920v2⟩

Share

Metrics

Record views

33

Files downloads

1